Decreased Systemic Levels of Endocan-1 and CXCL16 in Psoriasis Are Restored following Narrowband UVB Treatment.

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Sigurdardottir, Gunnthorunn,1975-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Center (författare)

Decreased Systemic Levels of Endocan-1 and CXCL16 in Psoriasis Are Restored following Narrowband UVB Treatment.

Artikel/kapitelEngelska2018

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2018-09-03
Basel :S. Karger,2018
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LIBRIS-ID:oai:DiVA.org:liu-151989
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151989URI
https://doi.org/10.1159/000491819DOI

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Språk:engelska
Sammanfattning på:engelska

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This research was funded by the Ingrid Asp Foundation, the Welander Foundation, the Swedish Psoriasis Association, and the Medical Research Council.
BACKGROUND: In psoriasis, a common immune-mediated disease affecting 2-3% of the population worldwide, there is an increased prevalence of extracutaneous diseases including obesity, the metabolic syndrome, and cardiovascular disease. This is believed to be linked to systemic inflammation. In previous studies, we have explored various markers in plasma and serum to characterize the ongoing systemic inflammation in psoriasis patients compared to controls. We have identified several markers that were altered in psoriasis patients, but which all were unresponsive to narrowband UVB (NB-UVB) treatment.OBJECTIVE: The objective of the study was to evaluate the effect of NB-UVB treatment on markers of cardiovascular risk and systemic inflammation in psoriasis.METHODS: The levels of 17 potential biomarkers with an association with cardiovascular risk were quantitated in plasma from 37 age- and gender-matched psoriasis patients and controls at baseline and in 21 psoriasis patients after 12 weeks of NB-UVB treatment to identify a systemic treatment response.RESULTS: We identified the mediators endocan-1, CXCL16, and sVEGFR1, which were systemically decreased in psoriasis at baseline, as well as FABP3, FABP4, and sIL-1R1, which showed normal baseline levels. After 10-12 weeks of NB-UVB treatment, endocan-1 and CXCL16 were restored to normal levels, while sVEGFR1, FABP3, FABP4, and sIL-1R1 showed a significant reduction.CONCLUSION: The current study expands the number of potential biomarkers in psoriasis by including a greater number and variety of mediators, approaching the systemic inflammation from additional vantage points, including soluble immune receptors and adipocyte contribution, to provide a more complete picture of the systemic inflammatory state in psoriasis.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
Cardiovascular risk
Psoriasis
Skin
UVB

Biuppslag (personer, institutioner, konferenser, titlar ...)

Ekman, Anna-Karin,1981-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Center(Swepub:liu)annek78 (författare)
Verma, Deepti,1969-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Ingrid Asp Psoriasis Research Center(Swepub:liu)deeve22 (författare)
Enerbäck, Charlotta,1965-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Ingrid Asp Psoriasis Research Center(Swepub:liu)chaen00 (författare)
Linköpings universitetAvdelningen för cellbiologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:DermatologyBasel : S. Karger234:5-6, s. 173-1791018-86651421-9832

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