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Biomaterials-enable...
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Islam, Mohammad Mirazul,1984-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Harvard Medical School, Boston, MA USA
(author)
Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-01-31
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Springer Science and Business Media LLC,2018
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-152526
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-152526URI
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https://doi.org/10.1038/s41536-017-0038-8DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The severe worldwide shortage of donor organs, and severe pathologies placing patients at high risk for rejecting conventional cornea transplantation, have left many corneal blind patients untreated. Following successful pre-clinical evaluation in mini-pigs, we tested a biomaterials-enabled pro-regeneration strategy to restore corneal integrity in an open-label observational study of six patients. Cell-free corneal implants comprising recombinant human collagen and phosphorylcholine were grafted by anterior lamellar keratoplasty into corneas of unilaterally blind patients diagnosed at high-risk for rejecting donor allografts. They were followed-up for a mean of 24 months. Patients with acute disease (ulceration) were relieved of pain and discomfort within 1-2 weeks post-operation. Patients with scarred or ulcerated corneas from severe infection showed better vision improvement, followed by corneas with burns. Corneas with immune or degenerative conditions transplanted for symptom relief only showed no vision improvement overall. However, grafting promoted nerve regeneration as observed by improved touch sensitivity to near normal levels in all patients tested, even for those with little/no sensitivity before treatment. Overall, three out of six patients showed significant vision improvement. Others were sufficiently stabilized to allow follow-on surgery to restore vision. Grafting outcomes in mini-pig corneas were superior to those in human subjects, emphasizing that animal models are only predictive for patients with non-severely pathological corneas; however, for establishing parameters such as stable corneal tissue and nerve regeneration, our pig model is satisfactory. While further testing is merited, we have nevertheless shown that cell-free implants are potentially safe, efficacious options for treating high-risk patients.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Buznyk, Oleksiy,1978-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine, Odessa, Ukraine(Swepub:liu)olebu51
(author)
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Reddy, Jagadesh CTej Kohli Cornea Institute, LV Prasad Eye Institute, Hyderabad, India
(author)
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Pasyechnikova, NataliyaFilatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine, Odessa, Ukraine
(author)
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Alarcon, Emilio IDivision of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON Canada
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Hayes, SallySchool of Optometry and Vision Sciences College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK; 7Cardiff Institute for Tissue Engineering and Repair (CITER), Cardiff University, Cardiff, UK
(author)
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Lewis, PhilipSchool of Optometry and Vision Sciences College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK; 7Cardiff Institute for Tissue Engineering and Repair (CITER), Cardiff University, Cardiff, UK
(author)
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Fagerholm, Per,1948-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US(Swepub:liu)perfa04
(author)
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He, ChaoliangKey Laboratory of Polymer Eco-materials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
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Iakymenko, StanislavFilatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine, Odessa, Ukraine
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Liu, WenguangSchool of Materials Science and Engineering, Tianjin University, Tianjin, China
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Meek, Keith MSchool of Optometry and Vision Sciences College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK; 7Cardiff Institute for Tissue Engineering and Repair (CITER), Cardiff University, Cardiff, UK
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Sangwan, Virender STej Kohli Cornea Institute, LV Prasad Eye Institute, Hyderabad, India
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Griffith, May,1961-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,University of Montreal, Montreal, Canada(Swepub:liu)maygr76
(author)
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Linköpings universitetAvdelningen för cellbiologi
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In:NPJ Regenerative medicine: Springer Science and Business Media LLC32057-3995
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