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Viral Persistence a...
Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion
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- Barathan, Muttiah (författare)
- Univ Malaya, Malaysia
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- Mohamed, Rosmawati (författare)
- Univ Malaya, Malaysia
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- Yong, Yean K. (författare)
- Xiamen Univ Malaysia, Malaysia
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- Kannan, Meganathan (författare)
- CUTN, India
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- Vadivelu, Jamuna (författare)
- Univ Malaya, Malaysia
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- Saeidi, Alireza (författare)
- Univ Malaya, Malaysia
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- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Shankar, Esaki Muthu (författare)
- CUTN, India
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(creator_code:org_t)
- 2018-10-12
- 2018
- Engelska.
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Ingår i: Cells. - : MDPI. - 2073-4409. ; 7:10
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Hepatitis C virus (HCV) represents a challenging global health threat to similar to 200 million infected individuals. Clinical data suggest that only similar to 10-15% of acutely HCV-infected individuals will achieve spontaneous viral clearance despite exuberant virus-specific immune responses, which is largely attributed to difficulties in recognizing the pathognomonic symptoms during the initial stages of exposure to the virus. Given the paucity of a suitable small animal model, it is also equally challenging to study the early phases of viral establishment. Further, the host factors contributing to HCV chronicity in a vast majority of acutely HCV-infected individuals largely remain unexplored. The last few years have witnessed a surge in studies showing that HCV adopts myriad mechanisms to disconcert virus-specific immune responses in the host to establish persistence, which includes, but is not limited to viral escape mutations, viral growth at privileged sites, and antagonism. Here we discuss a few hitherto poorly explained mechanisms employed by HCV that are believed to lead to chronicity in infected individuals. A better understanding of these mechanisms would aid the design of improved therapeutic targets against viral establishment in susceptible individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- apoptosis; viral persistence; hepatitis C virus; immunity; chronic infection
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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