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Sökning: WFRF:(Daskalakis J) > Deep TMS of the ins...

Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [C-11] PHNO-PET pilot trial in healthy humans

Malik, Saima (författare)
Ctr Addict and Mental Hlth, Canada
Jacobs, Mark (författare)
Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada
Cho, Sang-Soo (författare)
Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada
visa fler...
Boileau, Isabelle (författare)
Ctr Addict and Mental Hlth, Canada
Blumberger, Daniel (författare)
Univ Toronto, Canada; Ctr Addict and Mental Hlth, Canada; Ctr Addict and Mental Hlth, Canada
Heilig, Markus (författare)
Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken
Wilson, Alan (författare)
Ctr Addict and Mental Hlth, Canada
Daskalakis, Zafiris J. (författare)
Univ Toronto, Canada; Ctr Addict and Mental Hlth, Canada; Ctr Addict and Mental Hlth, Canada
Strafella, Antonio P. (författare)
Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada; Univ Toronto, Canada; Univ Toronto, Canada
Zangen, Abraham (författare)
Ben Gurion Univ Negev, Israel
Le Foll, Bernard (författare)
Ctr Addict and Mental Hlth, Canada; Univ Toronto, Canada; Ctr Addict and Mental Hlth, Canada; Ctr Addict and Mental Hlth, Canada
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 (creator_code:org_t)
2017-11-23
2018
Engelska.
Ingår i: Brain Imaging and Behavior. - : SPRINGER. - 1931-7557 .- 1931-7565. ; 12:5, s. 1306-1317
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Modulating the function of the insular cortex could be a novel therapeutic strategy to treat addiction to a variety of drugs of abuse as this region has been implicated in mediating drug reward and addictive processes. The recent advent of the H-coil has permitted the targeting of deeper brain structures which was not previously feasible. The goal of this study was to bilaterally target the insular region using the H-coil with repetitive Transcranial Magnetic Stimulation (rTMS) and subsequently measure changes in dopamine levels using Positron Emission Tomography (PET) with [11C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO). This was a within-subject, crossover, blinded and sham-controlled pilot study. Eight healthy, right-handed subjects, aged 19-45, participated in the investigation. All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1Hz or 10Hz), on 3 separate days. Low frequency rTMS (1Hz), targeting the insular cortex, significantly decreased dopamine levels in the substantia nigra, sensorimotor striatum and associative striatum. Replicating this study in tobacco smokers or alcoholics would be a logical follow-up to assess whether H-coil stimulation of the bilateral insula can be employed as a treatment option for addiction. Trial registration: NCT02212405

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Insula; PET; Dopamine; H-coil; Deep rTMS; PHNO

Publikations- och innehållstyp

ref (ämneskategori)
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