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Sökning: WFRF:(Storey Robert F.) > (2015-2019) > Pre-hospital admini...

  • Fabris, EnricoCardiology Department, Isala Heart Center, Zwolle, the Netherlands, , Cardiovascular Department, University of Trieste, Trieste, Italy (författare)

Pre-hospital administration of ticagrelor in diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty : A sub-analysis of the ATLANTIC trial

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2018-10-09
  • John Wiley & Sons,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-153879
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153879URI
  • https://doi.org/10.1002/ccd.27921DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies: Astrazeneca
  • OBJECTIVE: We investigated, in the contemporary era of ST-elevation myocardial infarction (STEMI) treatment, the influence of diabetes mellitus (DM) on cardiovascular outcomes, and whether pre-hospital administration of ticagrelor may affect these outcomes in a subgroup of STEMI patients with DM.BACKGROUND: DM patients have high platelet reactivity and a prothrombotic condition which highlight the importance of an effective antithrombotic regimen in this high-risk population.METHODS: In toal 1,630 STEMI patients enrolled in the ATLANTIC trial who underwent primary percutaneous coronary intervention (PCI) were included. Multivariate analysis was used to explore the association of DM with outcomes and potential treatment-by-diabetes interaction was tested.RESULTS: A total of 214/1,630 (13.1%) patients had DM. DM was an independent predictor of poor myocardial reperfusion as reflected by less frequent ST-segment elevation resolution (≥70%) after PCI (OR 0.59, 95% CI 0.43-0.82, P < 0.01) and was an independent predictor of the composite 30-day outcomes of death/new myocardial infarction (MI)/urgent revascularization/definite stent thrombosis (ST) (OR 2.80, 95% CI 1.62-4.85, P < 0.01), new MI or definite acute ST (OR 2.46, 95% CI 1.08-5.61, P = 0.03), and definite ST (OR 10.00, 95% CI 3.54-28.22, P < 0.01). No significant interaction between pre-hospital ticagrelor vs in-hospital ticagrelor administration and DM was present for the clinical, electrocardiographic and angiographic outcomes as well as for thrombolysis in myocardial infarction major bleeding.CONCLUSIONS: DM remains independently associated with poor myocardial reperfusion and worse 30-day clinical outcomes. No significant interaction was found between pre-hospital vs in-hospital ticagrelor administration and DM status. Further approaches for the treatment of DM patients are needed.CLINICAL TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01347580.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Van't Hof, ArnoudCardiology Department, Isala Heart Center, Zwolle, the Netherlands, Maastricht University Medical Center, Maastricht, the Netherlands, Zuyderland Hospital, Heerlen, the Netherlands (författare)
  • Hamm, Christian WKerckhoff Heart and Thorax Center, Bad Nauheim, Germany (författare)
  • Lapostolle, FrédéricSAMU 93 Hôpital Avicenne, Bobigny, France (författare)
  • Lassen, Jens FlenstedDepartment of Cardiology B, Aarhus University Hospital, Aarhus, Denmark (författare)
  • Goodman, Shaun GCanadian Heart Research Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Canada (författare)
  • Ten Berg, Jurriën MDepartment of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands (författare)
  • Bolognese, LeonardoCardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy (författare)
  • Cequier, AngelHeart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, Spain (författare)
  • Chettibi, MohamedCentre Hospito-universitaire Frantz Fanon, Blida, Algeria (författare)
  • Hammett, Christopher JDepartment of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia (författare)
  • Huber, Kurt3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen hospital and Sigmund Freud University, Medical School, Vienna, Austria. (författare)
  • Janzon, MagnusLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)magja75 (författare)
  • Merkely, BélaHeart and Vascular Center, Semmelweis University, Budapest, Hungary (författare)
  • Storey, Robert FDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom (författare)
  • Zeymer, UweKlinikum Ludwigshafen and Institut für Herzinfarktforschung, Ludwigshafen, Germany (författare)
  • Cantor, Warren JSouthlake Regional Health Centre, University of Toronto, Ontario, Canada (författare)
  • Kerneis, MathieuSorbonne Université, ACTION Study Group, Hospital Pitie-Salpetriere (AP-HP), Paris, France (författare)
  • Diallo, AbdourahmaneHospital Lariboisiere, ACTION Study Group, Paris, France (författare)
  • Vicaut, EricHospital Lariboisiere, ACTION Study Group, Paris, France (författare)
  • Montalescot, GillesSorbonne Université, ACTION Study Group, Hospital Pitie-Salpetriere (AP-HP), Paris, France (författare)
  • Cardiology Department, Isala Heart Center, Zwolle, the Netherlands, , Cardiovascular Department, University of Trieste, Trieste, ItalyCardiology Department, Isala Heart Center, Zwolle, the Netherlands, Maastricht University Medical Center, Maastricht, the Netherlands, Zuyderland Hospital, Heerlen, the Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Catheterization and cardiovascular interventions: John Wiley & Sons93:7, s. E369-E3771522-19461522-726X

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