Preventing Hot Spots in High Dose-Rate Brachytherapy

Morén, Björn,1987-Linköpings universitet,Optimeringslära,Tekniska fakulteten,Institutionen för medicin och hälsa (författare)

High dose-rate brachytherapy is a method of radiation cancer treatment, where the radiation source is placed inside the body. The recommended way to evaluate dose plans is based on dosimetric indices which are aggregate measures of the received dose. Insufficient spatial distribution of the dose may however result in hot spots, which are contiguous volumes in the tumour that receive a dose that is much too high. We use mathematical optimization to adjust a dose plan that is acceptable with respect to dosimetric indices to also take spatial distribution of the dose into account. This results in large-scale nonlinear mixed-binary models that are solved using nonlinear approximations. We show that there are substantial degrees of freedom in the dose planning even though the levels of dosimetric indices are maintained, and that it is possible to improve a dose plan with respect to its spatial properties.

Larsson, Torbjörn,1957-Linköpings universitet,Optimeringslära,Tekniska fakulteten(Swepub:liu)torla64 (författare)
Carlsson Tedgren, Åsa,1968-Medical Radiation Physics and Nuclear Medicine, Department of Oncology Pathology, Karolinska University Hospital, Solna Sweden(Swepub:liu)asaca90 (författare)
Linköpings universitetOptimeringslära (creator_code:org_t)

Ingår i:Operations Research Proceedings 2017Cham : Springer International Publishing, s. 369-37597833198991909783319899206

Av författaren/redakt...: Morén, Björn, 19 ...; Larsson, Torbjör ...; Carlsson Tedgren ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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