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Comparison of the D...
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Nous, Fay M. A.Erasmus MC, Netherlands; Erasmus MC, Netherlands
(författare)
Comparison of the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve in Patients With Versus Without Diabetes Mellitus (from the MACHINE Consortium)
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-155003
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-155003URI
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https://doi.org/10.1016/j.amjcard.2018.11.024DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Dutch Heart Foundation [NHS 2014T061, NHS 2013T071]
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Coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) is a noninvasive application to evaluate the hemodynamic impact of coronary artery disease by simulating invasively measured FFR based on CT data. CT-FFR is based on the assumption of a normal coronary microvascular response. We assessed the diagnostic performance of a machine-learning based application for on-site computation of CT-FFR in patients with and without diabetes mellitus with suspected coronary artery disease. The study population included 75 diabetic and 276 nondiabetic patients who were enrolled in the MACHINE consortium. The overall diagnostic performance of coronary CT angiography alone and in combination with CT-FFR were analyzed with direct invasive FFR comparison in 110 coronary vessels of the diabetic group and in 415 coronary vessels of the nondiabetic group. Per-vessel discrimination of lesion-specific ischemia by CT-FFR was assessed by the area under the receiver operating characteristic curves. The overall diagnostic accuracy of CT-FFR in diabetic patients was 83% and in nondiabetic patients 75% (p = 0.088), showing improvement over the diagnostic accuracy of coronary CT angiography, which was 58% and 65% (p = 0.223), respectively. In addition, the diagnostic accuracy of CT-FFR was similar between diabetic and nondiabetic patients per stratified CT-FFR group (CT-FFR amp;lt; 0.6, 0.6 to 0.69, 0.7 to 0.79, 0.8 to 0.89, amp;gt;= 0.9). The area under the curves for diabetic and nondiabetic patients were also comparable, 0.88 and 0.82 (p = 0.113), respectively. In conclusion, on-site machine-learning CT-FFR analysis improved the diagnostic performance of coronary CT angiography and accurately discriminated lesion-specific ischemia in both diabetic and nondiabetic patients suspected of coronary artery disease. (C) 2018 Elsevier Inc. All rights reserved.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Coenen, AdriaanErasmus MC, Netherlands; Erasmus MC, Netherlands
(författare)
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Boersma, EricErasmus MC, Netherlands
(författare)
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Kim, Young-HakUniv Ulsan, South Korea
(författare)
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Kruk, Mariusz B. P.Inst Cardiol, Poland
(författare)
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Tesche, ChristianMed Univ South Carolina, SC 29425 USA
(författare)
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De Geer, Jakob,1970-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping(Swepub:liu)jakde64
(författare)
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Yang, Dong HyunUniv Ulsan, South Korea; Univ Ulsan, South Korea
(författare)
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Kepka, CezaryInst Cardiol, Poland
(författare)
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Schoepf, U. JosephUniv Ulsan, South Korea
(författare)
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Persson, AndersLinköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping(Swepub:liu)andpe75
(författare)
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Kurata, AkiraErasmus MC, Netherlands; Ehime Univ, Japan
(författare)
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Budde, Ricardo P. J.Erasmus MC, Netherlands; Erasmus MC, Netherlands
(författare)
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Nieman, KoenErasmus MC, Netherlands; Erasmus MC, Netherlands; Stanford Univ, CA 94305 USA
(författare)
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Erasmus MC, Netherlands; Erasmus MC, NetherlandsErasmus MC, Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of Cardiology: EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC123:4, s. 537-5430002-91491879-1913
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Nous, Fay M. A.
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Coenen, Adriaan
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Boersma, Eric
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