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A mechanism for tem...
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Wunderer, JuliaUniv Innsbruck, Austria
(författare)
A mechanism for temporary bioadhesion
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-02-19
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NATL ACAD SCIENCES,2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-155532
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-155532URI
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https://doi.org/10.1073/pnas.1814230116DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Austrian Science Fund [P 25404-B25, P 30347, J 4071]; University of Innsbruck; Autonome Provinz Bozen; Austrian Academy of Sciences OAW; Tyrolian Science Fund TWF; European Cooperation in Science and Technology (COST) Actions [TD0906, CA15216]
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The flatworm Macrostomum lignano features a duo-gland adhesive system that allows it to repeatedly attach to and release from substrates in seawater within a minute. However, little is known about the molecules involved in this temporary adhesion. In this study, we show that the attachment of M. lignano relies on the secretion of two large adhesive proteins, M. lignano adhesion protein 1 (Mlig-ap1) and Mlig-ap2. We revealed that both proteins are expressed in the adhesive gland cells and that their distribution within the adhesive footprints was spatially restricted. RNA interference knockdown experiments demonstrated the essential function of these two proteins in flatworm adhesion. Negatively charged modified sugars in the surrounding water inhibited flatworm attachment, while positively charged molecules impeded detachment. In addition, we found that M. lignano could not adhere to strongly hydrated surfaces. We propose an attachment-release model where Mlig-ap2 attaches to the substrate and Mlig-ap1 exhibits a cohesive function. A small negatively charged molecule is secreted that interferes with Mlig-ap1, inducing detachment. These findings are of relevance for fundamental adhesion science and efforts to mitigate biofouling. Further, this model of flatworm temporary adhesion may serve as the starting point for the development of synthetic reversible adhesion systems for medicinal and industrial applications.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lengerer, BirgitUniv Innsbruck, Austria; Univ Mons, Belgium
(författare)
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Pjeta, RobertUniv Innsbruck, Austria
(författare)
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Bertemes, PhilipUniv Innsbruck, Austria
(författare)
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Kremser, LeopoldInnsbruck Med Univ, Austria
(författare)
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Lindner, HerbertInnsbruck Med Univ, Austria
(författare)
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Ederth, ThomasLinköpings universitet,Molekylär fysik,Tekniska fakulteten(Swepub:liu)thoed88
(författare)
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Hess, Michael W.Innsbruck Med Univ, Austria
(författare)
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Stock, DavidUniv Innsbruck, Austria
(författare)
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Salvenmoser, WilliUniv Innsbruck, Austria
(författare)
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Ladurner, PeterUniv Innsbruck, Austria
(författare)
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Univ Innsbruck, AustriaUniv Innsbruck, Austria; Univ Mons, Belgium
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Proceedings of the National Academy of Sciences of the United States of America: NATL ACAD SCIENCES116:10, s. 4297-43060027-84241091-6490
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Till lärosätets databas
- Av författaren/redakt...
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Wunderer, Julia
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Lengerer, Birgit
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Pjeta, Robert
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Bertemes, Philip
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Kremser, Leopold
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Lindner, Herbert
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visa fler...
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Ederth, Thomas
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Hess, Michael W.
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Stock, David
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Salvenmoser, Wil ...
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Ladurner, Peter
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biofysik
- Artiklar i publikationen
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Proceedings of t ...
- Av lärosätet
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Linköpings universitet