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Incidence of Capill...
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Jeong, Gwang HunGyeongsang Natl Univ, South Korea
(author)
Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-26
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MDPI,2019
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-155590
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-155590URI
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https://doi.org/10.3390/jcm8020143DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140435036URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Capillary leak syndrome (CLS) is a rare disease with profound vascular leakage, which can be associated with a high mortality. There have been several reports on CLS as an adverse effect of anti-cancer agents and therapy, but the incidence of CLS according to the kinds of anti-cancer drugs has not been systemically evaluated. Thus, the aim of our study was to comprehensively meta-analyze the incidence of CLS by different types of cancer treatment or after bone marrow transplantation (BMT). We searched the literatures (inception to July 2018) and among 4612 articles, 62 clinical trials (studies) were eligible. We extracted the number of patients with CLS, total cancer patients, name of therapeutic agent and dose, and type of cancer. We performed a meta-analysis to estimate the summary effects with 95% confidence interval and between-study heterogeneity. The reported incidence of CLS was categorized by causative drugs and BMT. The largest number of studies reported on CLS incidence during interleukin-2 (IL-2) treatment (n = 18), which yielded a pooled incidence of 34.7% by overall estimation and 43.9% by meta-analysis. The second largest number of studies reported on anti-cluster of differentiation (anti-CD) agents (n = 13) (incidence of 33.9% by overall estimation and 35.6% by meta-analysis) or undergoing BMT (n = 7 (21.1% by overall estimation and 21.7% by meta-analysis). Also, anti-cancer agents, including IL-2 + imatinib mesylate (three studies) and anti-CD22 monoclinal antibodies (mAb) (four studies), showed a dose-dependent increase in the incidence of CLS. Our study is the first to provide an informative overview on the incidence rate of reported CLS patients as an adverse event of anti-cancer treatment. This meta-analysis can lead to a better understanding of CLS and assist physicians in identifying the presence of CLS early in the disease course to improve the outcome and optimize management.
Subject headings and genre
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Lee, Keum HwaYonsei Univ, South Korea; Severance Childrens Hosp, South Korea; Yonsei Univ, South Korea
(author)
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Lee, I. ReYonsei Univ, South Korea; Severance Childrens Hosp, South Korea
(author)
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Oh, Ji HyunWonkwang Univ, South Korea
(author)
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Kim, Dong WookYonsei Univ, South Korea
(author)
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Shin, Jae WonYonsei Univ, South Korea
(author)
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Kronbichler, AndreasMed Univ Innsbruck, Austria
(author)
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Eisenhut, MichaelLutonand Dunstable Univ Hosp NHS Fdn Trust, England
(author)
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van der Vliet, Hans J.Vrije Univ Amsterdam, Netherlands
(author)
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Abdel-Rahman, OmarAin Shams Univ, Egypt; Univ Calgary, Canada
(author)
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Stubbs, BrendonKings Coll London, England; South London and Maudsley NHS Fdn Trust, England; Anglia Ruskin Univ, England
(author)
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Solmi, MarcoUniv Padua, Italy
(author)
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Veronese, NicolaCNR, Italy
(author)
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Dragioti, Elena,Ph.D.Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum(Swepub:liu)eledr71
(author)
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Koyanagi, AiUniv Barcelona, Spain
(author)
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Radua, JoaquimKarolinska Institutet,Inst Invest Biomed August Pi i Sunyer IDIBAPS, Spain; Mental Hlth Res Networking Ctr CIBERSAM, Spain; Kings Coll London, England; Karolinska Inst, Sweden
(author)
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Shin, Jae IlYonsei Univ, South Korea; Severance Childrens Hosp, South Korea; Yonsei Univ, South Korea
(author)
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Gyeongsang Natl Univ, South KoreaYonsei Univ, South Korea; Severance Childrens Hosp, South Korea; Yonsei Univ, South Korea
(creator_code:org_t)
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In:Journal of Clinical Medicine: MDPI8:22077-0383
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Jeong, Gwang Hun
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Lee, Keum Hwa
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Lee, I. Re
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Oh, Ji Hyun
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Kim, Dong Wook
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Shin, Jae Won
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Kronbichler, And ...
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Eisenhut, Michae ...
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van der Vliet, H ...
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Abdel-Rahman, Om ...
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Stubbs, Brendon
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Solmi, Marco
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Veronese, Nicola
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Dragioti, Elena, ...
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Koyanagi, Ai
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Radua, Joaquim
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Shin, Jae Il
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Linköping University
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Karolinska Institutet