Higher levels of SDMA and not ADMA are associated with poorer survival of trial patients with systemic ANCA-associated vasculitis

Erdbrügger, UtaDivision of Nephrology, Department of Medicine, University of Virginia Health System, Virginia, USA (författare)

Endothelial dysfunction, increased cardiovascular events (CVE), and accelerated atherosclerosis have been described in patients with small vessel vasculitis and collagen vascular disease. Identifying predictors of cardiovascular risk will help to optimize short- and long-term care of patients with vasculitis. The present study investigates the predictive role of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and its stereoisomer symmetric dimethylarginine (SDMA) for cardiovascular risk, all-cause mortality, and renal function in patients with anti-neutrophil-cytoplasmic antibodies-associated small vessel vasculitis (AASV) subjected to standardized treatment regimens in four European Vasculitis Study Group trials representing all stages of renal disease.

Kielstein, Jan TDepartment of Hypertension and Nephrology, Medical Clinic V, Klinikum Braunschweig, Braunschweig, Germany (författare)
Westman, KerstinDepartment of Nephrology, Lund University, Lund, Sweden (författare)
Ma, Jennie ZDepartment of Biostatistics, University of Virginia Health System, Virginia, USA (författare)
Xin, WenjunDepartment of Biostatistics, University of Virginia Health System, Virginia, USA (författare)
Bode-Böger, Stephanie MOtto-von-Guericke University, Institute of Clinical Pharmacology, Magdeburg, Germany (författare)
Segelmark, Mårten,1957-Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US(Swepub:liu)marse71 (författare)
Rasmussen, NielsDepartment of Biochemistry and Immunology, Statens Seruminstitut, Copenhagen, Denmark (författare)
De Groot, KirstenDepartment of Nephrology and Rheumatology, Medical Clinic III, Sana Klinikum, Offenbach, Germany (författare)
Division of Nephrology, Department of Medicine, University of Virginia Health System, Virginia, USADepartment of Hypertension and Nephrology, Medical Clinic V, Klinikum Braunschweig, Braunschweig, Germany (creator_code:org_t)

Av författaren/redakt...: Erdbrügger, Uta; Kielstein, Jan T; Westman, Kerstin; Ma, Jennie Z; Xin, Wenjun; Bode-Böger, Step ...; visa fler...; Segelmark, Mårte ...; Rasmussen, Niels; De Groot, Kirste ...; visa färre...

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