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A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models

Dhanani, Jayesh A (författare)
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia. jadhanani@hotmail.com; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia. jadhanani@hotmail.com; Critical Care Research Group, The University of Queensland, Brisbane, Australia
Cohen, Jeremy (författare)
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia
Parker, Suzanne L (författare)
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia
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Chan, Hak-Kim (författare)
Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
Tang, Patricia (författare)
Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
Ahern, Benjamin J (författare)
Faculty of Science, School of Veterinary Science, The University of Queensland, Gatton, Australia
Khan, Adeel (författare)
Faculty of Science, School of Veterinary Science, The University of Queensland, Gatton, Australia
Bhatt, Manoj (författare)
Department of Nuclear Medicine and Specialised PET Services Queensland, Royal Brisbane and Womens Hospital, Herston, Queensland, Australia; School of Medicine, Faculty of Health Sciences, University of Queensland, St Lucia, Queensland, Australia
Goodman, Steven (författare)
Department of Nuclear Medicine and Specialised PET Services Queensland, Royal Brisbane and Womens Hospital, Herston, Queensland, Australia
Diab, Sara (författare)
Critical Care Research Group, The University of Queensland, Brisbane, Australia
Chaudhary, Jivesh (författare)
Critical Care Research Group, The University of Queensland, Brisbane, Australia
Lipman, Jeffrey (författare)
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia; Faculty of Health, Queensland University of Technology, Brisbane, Australia
Wallis, Steven C (författare)
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia
Barnett, Adrian (författare)
Institute of Health and Biomedical Innovation and School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Brisbane, Australia
Chew, Michelle S, 1969- (författare)
Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, ANOPIVA US
Fraser, John F (författare)
Critical Care Research Group, The University of Queensland, Brisbane, Australia
Roberts, Jason A (författare)
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Australia; Department of Pharmacy, Royal Brisbane and Womens Hospital, Brisbane, Australia
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Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia jadhanani@hotmail.com; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia. jadhanani@hotmail.com; Critical Care Research Group, The University of Queensland, Brisbane, Australia Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia (creator_code:org_t)
2018-07-11
2018
Engelska.
Ingår i: Intensive Care Medicine Experimental. - : Springer Science and Business Media LLC. - 2197-425X. ; 6:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Nebulised antibiotics are frequently used for the prevention or treatment of ventilator-associated pneumonia. Many factors may influence pulmonary drug concentrations with inaccurate dosing schedules potentially leading to therapeutic failure and/or the emergence of antibiotic resistance. We describe a research pathway for studying the pharmacokinetics of a nebulised antibiotic during mechanical ventilation using in vitro methods and ovine models, using tobramycin as the study antibiotic.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Inhaled mass; Microdialysis; Nebulised antibiotics; Particle size distribution; Regional drug distribution; Ventilator-associated pneumonia

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