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A research pathway ...
A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models
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- Dhanani, Jayesh A (författare)
- Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia. jadhanani@hotmail.com; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia. jadhanani@hotmail.com; Critical Care Research Group, The University of Queensland, Brisbane, Australia
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- Cohen, Jeremy (författare)
- Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia
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- Parker, Suzanne L (författare)
- Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia
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- Chan, Hak-Kim (författare)
- Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
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- Tang, Patricia (författare)
- Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
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- Ahern, Benjamin J (författare)
- Faculty of Science, School of Veterinary Science, The University of Queensland, Gatton, Australia
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- Khan, Adeel (författare)
- Faculty of Science, School of Veterinary Science, The University of Queensland, Gatton, Australia
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- Bhatt, Manoj (författare)
- Department of Nuclear Medicine and Specialised PET Services Queensland, Royal Brisbane and Womens Hospital, Herston, Queensland, Australia; School of Medicine, Faculty of Health Sciences, University of Queensland, St Lucia, Queensland, Australia
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- Goodman, Steven (författare)
- Department of Nuclear Medicine and Specialised PET Services Queensland, Royal Brisbane and Womens Hospital, Herston, Queensland, Australia
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- Diab, Sara (författare)
- Critical Care Research Group, The University of Queensland, Brisbane, Australia
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- Chaudhary, Jivesh (författare)
- Critical Care Research Group, The University of Queensland, Brisbane, Australia
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- Lipman, Jeffrey (författare)
- Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia; Faculty of Health, Queensland University of Technology, Brisbane, Australia
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- Wallis, Steven C (författare)
- Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia
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- Barnett, Adrian (författare)
- Institute of Health and Biomedical Innovation and School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Brisbane, Australia
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- Chew, Michelle S, 1969- (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Fraser, John F (författare)
- Critical Care Research Group, The University of Queensland, Brisbane, Australia
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- Roberts, Jason A (författare)
- Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Australia; Department of Pharmacy, Royal Brisbane and Womens Hospital, Brisbane, Australia
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Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia jadhanani@hotmail.com; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia. jadhanani@hotmail.com; Critical Care Research Group, The University of Queensland, Brisbane, Australia Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia (creator_code:org_t)
- 2018-07-11
- 2018
- Engelska.
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Ingår i: Intensive Care Medicine Experimental. - : Springer Science and Business Media LLC. - 2197-425X. ; 6:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://icm-experime...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Nebulised antibiotics are frequently used for the prevention or treatment of ventilator-associated pneumonia. Many factors may influence pulmonary drug concentrations with inaccurate dosing schedules potentially leading to therapeutic failure and/or the emergence of antibiotic resistance. We describe a research pathway for studying the pharmacokinetics of a nebulised antibiotic during mechanical ventilation using in vitro methods and ovine models, using tobramycin as the study antibiotic.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Inhaled mass; Microdialysis; Nebulised antibiotics; Particle size distribution; Regional drug distribution; Ventilator-associated pneumonia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Dhanani, Jayesh ...
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Cohen, Jeremy
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Parker, Suzanne ...
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Chan, Hak-Kim
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Tang, Patricia
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Ahern, Benjamin ...
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visa fler...
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Khan, Adeel
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Bhatt, Manoj
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Goodman, Steven
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Diab, Sara
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Chaudhary, Jives ...
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Lipman, Jeffrey
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Wallis, Steven C
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Barnett, Adrian
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Chew, Michelle S ...
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Fraser, John F
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Roberts, Jason A
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
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Intensive Care M ...
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