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Primary Prevention ...
Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillator Therapy in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
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- Platonov, Pyotr G. (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Haugaa, Kristina H. (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway,University of Oslo,Norwegian Radium Hospital
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- Bundgaard, Henning (author)
- Univ Copenhagen, Denmark; Univ Copenhagen, Denmark,University of Copenhagen
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- Svensson, Anneli (author)
- Linköping University,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Gilljam, Thomas (author)
- Sahlgrens Univ Hosp, Sweden,Sahlgrenska University Hospital
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- Hansen, Jim (author)
- Univ Copenhagen, Denmark,University of Copenhagen
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- Madsen, Trine (author)
- Aalborg Univ Hosp, Denmark,Aalborg University
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- Host, Anders Gaarsdal (author)
- Univ Copenhagen, Denmark,University of Copenhagen
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- Carlson, Jonas (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Lie, Oyvind H. (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway,University of Oslo,Norwegian Radium Hospital
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- Jensen, Morten Kvistholm (author)
- Aarhus Univ Hosp, Denmark,Aarhus University Hospital
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- Edvardsen, Thor (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway,University of Oslo,Norwegian Radium Hospital
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- Jensen, Henrik K. (author)
- Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark,Aarhus University Hospital
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- Svendsen, Jesper H. (author)
- Univ Copenhagen, Denmark,University of Copenhagen
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(creator_code:org_t)
- EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2019
- 2019
- English.
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In: American Journal of Cardiology. - : EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC. - 0002-9149 .- 1879-1913. ; 123:7, s. 1156-1162
- Related links:
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https://www.duo.uio....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- Implantable cardioverter-defibrillator (ICD) therapy remains a corner stone of sudden cardiac death (SCD) prevention in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to assess predictors of appropriate ICD therapies in the Scandinavian cohort of ARVC patients who received ICD for primary prevention of SCD. Study group comprised of 79 definite ARVC patients by 2010 Task Force criteria (60% male, age at ICD implant 39 +/- 14 years) who were enrolled in the Nordic ARVC Registry and received an ICD for primary SCD prevention. The primary end point of appropriate ICD shock or death from any cause was assessed and compared with 137 definite ARVC patients who received ICD for secondary SCD prevention (74% male, age at ICD implant 42 +/- 15 years). In the study group, 38% were amp;lt;= 35 years of age at baseline, 25% had non-sustained ventricular tachycardia, and 29% had syncope at baseline. Major repolarization abnormality (hazard ratio = 4.00, 95% confidence interval 1.30 to 12.30, p = 0.015) and age amp;lt;= 35 years (hazard ratio = 4.21, 95% confidence interval 1.49 to 11.85, p = 0.001) independently predicted the primary end point. The outcome did not differ between the primary prevention patients with either of these risk factors and the secondary prevention cohort (2% to 4% annual event rate) whereas patients without risk factors did not have any appropriate ICD shocks during follow-up. In conclusion, young age at ARVC diagnosis and major repolarization abnormality independently predict ICD shocks or death in the primary prevention ICD recipients and associated with the event rate similar to the one observed in the secondary prevention cohort. Our data indicate the benefit of ICD for primary prevention in patients with any of these risk factors. (C) 2019 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Platonov, Pyotr ...
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Haugaa, Kristina ...
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Bundgaard, Henni ...
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Svensson, Anneli
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Gilljam, Thomas
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Hansen, Jim
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Madsen, Trine
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Host, Anders Gaa ...
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Carlson, Jonas
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Lie, Oyvind H.
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Jensen, Morten K ...
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Edvardsen, Thor
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Jensen, Henrik K ...
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Svendsen, Jesper ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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American Journal ...
- By the university
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Linköping University
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Lund University