Real World: Eligibility for Sacubitril/Valsartan in Unselected Heart Failure Patients: Data from the Swedish Heart Failure Registry

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Simpson, JoanneUniv Glasgow, Scotland (författare)

Real World : Eligibility for Sacubitril/Valsartan in Unselected Heart Failure Patients: Data from the Swedish Heart Failure Registry

Artikel/kapitelEngelska2019

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2019-03-23
SPRINGER,2019
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-158048
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158048URI
https://doi.org/10.1007/s10557-019-06873-1DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:141032678URI

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Språk:engelska
Sammanfattning på:engelska

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Funding Agencies|Swedish National board of Health and Welfare; Swedish Association of Local Authorities and Regions; Swedish Society of Cardiology; Swedish Heart-Lung Foundation
PurposePARADIGM-HF demonstrated the superiority of sacubitril/valsartan over enalapril in patients with heart failure and reduced ejection fraction (HF-REF). How widely applicable sacubitril/valsartan treatment is in unselected patients with HF-REF is not known. We examined eligibility of patients with HF-REF for treatment with sacubitril/valsartan, according to the criteria used in PARADIGM-HF, in the Swedish Heart Failure Registry (SwedeHF).MethodsPatients were considered potentially eligible if they were not hospitalized, had symptoms (NYHA class II-IV) and a reduced LVEF (40%), and were prescribed an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) at a dose equivalent to enalapril 10mg daily. In these patients, we evaluated further eligibility according to the main additional PARADIGM-HF inclusion criteria.ResultsOf 12,866 outpatients in NYHA functional class II-IV with an LVEF 40%, 9577 were prescribed at least 10mg of enalapril (or equivalent) daily. Complete additional data were available for 3099 of these patients (32.4%) and of them 75.5% were potentially eligible for treatment with sacubitril/valsartan. The most common reason for ineligibility was a low natriuretic peptide level (n=462, 14.9%). Only a small proportion of patients were ineligible due to low eGFR or serum potassium level. Because only 78% of patients were taking 10mg enalapril or equivalent daily, only 58.9% of all patients (75.5% of 78%) were eligible for sacubitril/valsartan.ConclusionsBetween 34 and 76% of symptomatic patients with HF-REF in a real world population are eligible for treatment with sacubitril/valsartan, depending on background ACEI/ARB dose. The most common reason for ineligibility is a low natriuretic peptide level.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Heart failure; Eligibility; Sacubitril-valsartan; Real-world population; PARADIGM-HF

Biuppslag (personer, institutioner, konferenser, titlar ...)

Benson, L.Karolinska Institutet,Soder Sjukhuset, Sweden (författare)
Jhund, P. S.Univ Glasgow, Scotland (författare)
Dahlström, UlfLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Karolinska Inst, Sweden(Swepub:liu)ulfda85 (författare)
McMurray, J. J. V.Univ Glasgow, Scotland (författare)
Lund, L. H.Karolinska Institutet,Karolinska Univ Hosp, Sweden (författare)
Karolinska InstitutetUniv Glasgow, Scotland (creator_code:org_t)

Sammanhörande titlar

Ingår i:Cardiovascular Drugs and Therapy: SPRINGER33:3, s. 315-3220920-32061573-7241

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Av författaren/redakt...: Simpson, Joanne; Benson, L.; Jhund, P. S.; Dahlström, Ulf; McMurray, J. J. ...; Lund, L. H.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Linköpings universitet; Karolinska Institutet

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