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Genomic and Functio...
Genomic and Functional Analysis of Emerging Virulent and Multidrug-Resistant Escherichia coli Lineage Sequence Type 648
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- Schaufler, Katharina (författare)
- Ernst Moritz Arndt Univ Greifswald, Germany; Free Univ Berlin, Germany
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- Semmler, Torsten (författare)
- Robert Koch Inst, Germany
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- Wieler, Lothar H. (författare)
- Robert Koch Inst, Germany
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- Trott, Darren J. (författare)
- Univ Adelaide, Australia
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- Pitout, Johann (författare)
- Calgary Lab Serv, Canada; Univ Calgary, Canada
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- Peirano, Gisele (författare)
- Calgary Lab Serv, Canada; Univ Calgary, Canada
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- Bonnedahl, Jonas (författare)
- Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Kalmar Cty Council, Sweden
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- Dolejska, Monika (författare)
- Univ Vet and Pharmaceut Sci Brno, Czech Republic; Univ Vet and Pharmaceut Sci Brno, Czech Republic
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- Literak, Ivan (författare)
- Univ Vet and Pharmaceut Sci Brno, Czech Republic; Univ Vet and Pharmaceut Sci Brno, Czech Republic
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- Fuchs, Stephan (författare)
- Robert Koch Inst, Germany
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- Ahmed, Niyaz (författare)
- Int Ctr Diarrheal Dis Res Bangladesh, Bangladesh
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- Grobbel, Mirjam (författare)
- German Fed Inst Risk Assessment, Germany
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- Torres, Carmen (författare)
- Univ La Rioja, Spain
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- McNally, Alan (författare)
- Univ Birmingham, England
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- Pickard, Derek (författare)
- Wellcome Trust Sanger Inst, England
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- Ewers, Christa (författare)
- Justus Liebig Univ Giessen, Germany
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- Croucher, Nicholas J. (författare)
- Imperial Coll, England
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- Corander, Jukka (författare)
- Wellcome Trust Sanger Inst, England; Univ Helsinki, Finland; Univ Oslo, Norway
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- Guenther, Sebastian (författare)
- Free Univ Berlin, Germany; Ernst Moritz Arndt Univ Greifswald, Germany
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(creator_code:org_t)
- AMER SOC MICROBIOLOGY, 2019
- 2019
- Engelska.
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Ingår i: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 63:6
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The pathogenic extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli lineage ST648 is increasingly reported from multiple origins. Our study of a large and global ST648 collection from various hosts (87 whole-genome sequences) combining core and accessory genomics with functional analyses and in vivo experiments suggests that ST648 is a nascent and generalist lineage, lacking clear phylogeographic and host association signals. By including large numbers of ST131 (n = 107) and ST10 (n = 96) strains for comparative genomics and phenotypic analysis, we demonstrate that the combination of multidrug resistance and high-level virulence are the hallmarks of ST648, similar to international high-risk clonal lineage ST131. Specifically, our in silico, in vitro, and in vivo results demonstrate that ST648 is well equipped with biofilm-associated features, while ST131 shows sophisticated signatures indicative of adaption to urinary tract infection, potentially conveying individual ecological niche adaptation. In addition, we used a recently developed NFDS (negative frequency-dependent selection) population model suggesting that ST648 will increase significantly in frequency as a cause of bacteremia within the next few years. Also, ESBL plasmids impacting biofilm formation aided in shaping and maintaining ST648 strains to successfully emerge worldwide across different ecologies. Our study contributes to understanding what factors drive the evolution and spread of emerging international high-risk clonal lineages.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- ESBL-producing clonal lineages; MDR; NFDS modeling; ST648; biofilm formation; phylogenetics; virulence
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Schaufler, Katha ...
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Semmler, Torsten
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Wieler, Lothar H ...
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Trott, Darren J.
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Pitout, Johann
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Peirano, Gisele
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visa fler...
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Bonnedahl, Jonas
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Dolejska, Monika
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Literak, Ivan
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Fuchs, Stephan
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Ahmed, Niyaz
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Grobbel, Mirjam
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Torres, Carmen
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McNally, Alan
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Pickard, Derek
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Ewers, Christa
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Croucher, Nichol ...
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Corander, Jukka
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Guenther, Sebast ...
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Antimicrobial Ag ...
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Linköpings universitet