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  • Seferovic, Petar M.Univ Belgrade, Serbia; Serbian Acad Arts and Sci, Serbia,Univ Brescia, Italy (author)

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-04-16
  • WILEY,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-158844
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158844URI
  • https://doi.org/10.1002/ejhf.1461DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141135242URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies. In DCM, HF with reduced ejection fraction (HFrEF) has high incidence and prevalence and represents the most frequent cause of death, despite improvements in treatment. In addition, advanced HF in DCM is one of the leading indications for heart transplantation. In HCM, HF with preserved ejection (HFpEF) affects most patients with obstructive, and similar to 10% of patients with non-obstructive HCM. A timely treatment is important, since development of advanced HF, although rare in HCM, portends a poor prognosis. In RCM, HFpEF is common, while HFrEF occurs later and more frequently in amyloidosis or iron overload/haemochromatosis. Irrespective of RCM aetiology, HF is a harbinger of a poor outcome. Recent advances in our understanding of the mechanisms underlying the development of HF in cardiomyopathies have significant implications for therapeutic decision-making. In addition, new aetiology-specific treatment options (e.g. enzyme replacement therapy, transthyretin stabilizers, immunoadsorption, immunotherapy, etc.) have shown a potential to improve outcomes. Still, causative therapies of many cardiomyopathies are lacking, highlighting the need for the development of effective strategies to prevent and treat HF in cardiomyopathies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Polovina, MarijaUniv Belgrade, Serbia; Clin Ctr Serbia, Serbia (author)
  • Bauersachs, JohannMed Sch Hannover, Germany (author)
  • Arad, MichaelTel Aviv Univ, Israel (author)
  • Ben Gal, TuviaTel Aviv Univ, Israel (author)
  • Lund, Lars H.Karolinska Institutet,Karolinska Univ Hosp, Sweden (author)
  • Felix, Stephan B.Univ Med Greifswald, Germany (author)
  • Arbustini, EloisaUniv Hosp Policlin San Matteo, Italy (author)
  • Caforio, Alida L. P.Univ Padua, Italy (author)
  • Farmakis, DimitriosUniv Cyprus, Cyprus; Univ Athens, Greece (author)
  • Filippatos, Gerasimos S.Univ Cyprus, Cyprus; Univ Athens, Greece (author)
  • Gialafos, EliasHenry Dunant Hosp, Greece (author)
  • Kanjuh, VladimirSerbian Acad Arts and Sci, Serbia (author)
  • Krljanac, GordanaUniv Belgrade, Serbia; Clin Ctr Serbia, Serbia (author)
  • Limongelli, GiuseppeUniv Campania Luigi Vanvitelll, Italy; UCL Inst Cardiovasc Sci, England (author)
  • Linhart, AlesCharles Univ Prague, Czech Republic (author)
  • Lyon, Alexander R.Imperial Coll London, England; Royal Brompton Hosp, England (author)
  • Maksimovic, RuzicaUniv Belgrade, Serbia; Clin Ctr Serbia, Serbia (author)
  • Milicic, DavorUniv Zagreb, Croatia (author)
  • Milinkovic, IvanClin Ctr Serbia, Serbia (author)
  • Noutsias, MichelMartin Luther Univ Halle Wittenberg, Germany (author)
  • Oto, AliHacettepe Univ, Turkey (author)
  • Oto, OztekinDokuz Eylul Univ, Turkey (author)
  • Pavlovic, Sinisa U.Univ Belgrade, Serbia; Clin Ctr Serbia, Serbia (author)
  • Piepoli, Massimo F.Guglielmo da Saliceto Hosp, Italy (author)
  • Ristic, Arsen D.Univ Belgrade, Serbia; Clin Ctr Serbia, Serbia (author)
  • Rosano, Giuseppe M. C.IRCCS San Raffaele, Italy; Univ London, England,Univ Basel, Switzerland; Univ Basel, Switzerland (author)
  • Seggewiss, HubertKlinikum Wurzburg Mitte, Germany (author)
  • Asanin, MilikaUniv Belgrade, Serbia; Clin Ctr Serbia, Serbia (author)
  • Seferovic, Jelena R.Univ Belgrade, Serbia; Harvard Med Sch, MA 02115 USA; Univ Belgrade, Serbia (author)
  • Ruschitzka, FrankUniv Heart Ctr, Switzerland (author)
  • Celutkiene, JelenaVilnius Univ, Lithuania; State Res Inst Ctr Innovat Med, Lithuania (author)
  • Jaarsma, TinyLinköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten(Swepub:liu)tinja77 (author)
  • Mueller, ChristianUniv Basel, Switzerland; Univ Basel, Switzerland (author)
  • Moura, BrendaCtr Hosp Sao Joao, Portugal (author)
  • Hill, LoreenaQueens Univ Belfast, North Ireland (author)
  • Volterrani, MaurizioIRCCS San Raffaele Pisana, Italy (author)
  • Lopatin, YuriVolgograd State Med Univ, Russia (author)
  • Metra, MarcoUniv Brescia, Italy (author)
  • Backs, JohannesHeidelberg Univ, Germany; DZHK German Ctr Cardiovasc Res, Germany (author)
  • Mullens, WilfriedHasselt Univ, Belgium; Ziekenhuis Oost Limburg, Belgium (author)
  • Chioncel, OvidiuUniv Med and Pharm Carol Davila, Romania; Emergency Inst Cardiovasc Dis Prof CC Iliescu, Romania (author)
  • de Boer, Rudolf A.Univ Groningen, Netherlands (author)
  • Anker, StefanDept Cardiol CVK, Germany; Berlin Brandenburg Ctr Regenerat Therapies BCRT, Germany; DZHK German Ctr Cardiovasc Res, Germany (author)
  • Rapezzi, ClaudioAlma Mater Studiorum Univ Bologna, Italy (author)
  • Coats, Andrew J. sMonash Univ, Australia; Univ Warwick, England; IRCCS San Raffaele Pisana, Italy; St Georges Univ London, England (author)
  • Tschoepes, CarstenCharite Univ Med Berlin, Germany (author)
  • Univ Belgrade, Serbia; Serbian Acad Arts and Sci, SerbiaUniv Brescia, Italy (creator_code:org_t)

Related titles

  • In:European Journal of Heart Failure: WILEY21:5, s. 553-5761388-98421879-0844

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