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  • Patra, Hirak Kumar,1981-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Department of Chemical Engineering and Biotechnology, Cambridge University, Cambridge, UK; Wolfson College, University of Cambridge, Cambridge, UK (author)

Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-07-15
  • John Wiley & Sons,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-159097
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159097URI
  • https://doi.org/10.1002/adfm.201903760DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396138URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141427542URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; MIIC Strategic Postdoc Grant; MIIC Seed Grant at Linkoping University (LiU), Sweden
  • Cornea diseases are a leading cause of blindness and the disease burden is exacerbated by the increasing shortage around the world for cadaveric donor corneas. Despite the advances in the field of regenerative medicine, successful transplantation of laboratory‐made artificial corneas is not fully realized in clinical practice. The causes of failure of such artificial corneal implants are multifactorial and include latent infections from viruses and other microbes, enzyme overexpression, implant degradation, extrusion or delayed epithelial regeneration. Therefore, there is an urgent unmet need for developing customized corneal implants to suit the host environment and counter the effects of inflammation or infection, which are able to track early signs of implant failure in situ. This work reports a nanotoolbox comprising tools for protection from infection, promotion of regeneration, and noninvasive monitoring of the in situ corneal environment. These nanosystems can be incorporated within pro‐regenerative biosynthetic implants, transforming them into theranostic devices, which are able to respond to biological changes following implantation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Azharuddin, Mohammad,1986-Linköpings universitet,Avdelningen för klinisk kemi,Medicinska fakulteten(Swepub:liu)mohaz22 (author)
  • Islam, Mohammad Mirazul,1984-Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, USA(Swepub:liu)mohis64 (author)
  • Papapavlou, Georgia,1990-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)geopa97 (author)
  • Deb, Suryyani,1979-Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Department of Biochemistry, University of Calcutta, Calcutta, India; Department of Biotechnology, Maulana Abul Kalam Azad University of Technology (MAKAUT), West Bengal, India(Swepub:liu)surde90 (author)
  • Osterrieth, JohannesDepartment of Chemical Engineering and Biotechnology, Cambridge University, Philippa Fawcett Drive, Cambridge, UK (author)
  • Zhu, Geyunjian HarryDepartment of Chemical Engineering and Biotechnology, Cambridge University, Philippa Fawcett Drive, Cambridge, UK (author)
  • Romu, Thobias,1984-Linköpings universitet,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)thoro52 (author)
  • Dhara, Ashis KumarUppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion,Centre for Image Analysis, Uppsala University, Uppsala, Sweden; Department of Electrical Engineering, National Institute of Technology Durgapur, West Bengal, India(Swepub:uu)ashdh953 (author)
  • Jafari, Mohammad Javad,1984-Linköpings universitet,Molekylär fysik,Tekniska fakulteten(Swepub:liu)mohja16 (author)
  • Gadheri, AminehDepartment of Oncology‐Pathology, Karolinska Institute, Stockholm, Sweden (author)
  • Hinkula, Jorma,1958-Linköpings universitet,Avdelningen för hematopoes och utvecklingsbiologi,Medicinska fakulteten(Swepub:liu)jorhi40 (author)
  • Rajan, Madhavan S.Department of Ophthalmology, Cambridge University Hospitals NHS Trust and Vision and Eye Research Institute (VERI), Anglia Ruskin University, Cambridge, UK (author)
  • Slater, Nigel K. H.Department of Chemical Engineering and Biotechnology, Cambridge University, Philippa Fawcett Drive, Cambridge, UK (author)
  • Linköpings universitetAvdelningen för cellbiologi (creator_code:org_t)

Related titles

  • In:Advanced Functional Materials: John Wiley & Sons29:381616-301X1616-3028

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