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Dissemination of ex...
Dissemination of extended-spectrum beta-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health
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- Ji, Xiang (författare)
- Shandong Univ, Peoples R China
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- Zheng, Beiwen (författare)
- Zhejiang Univ, Peoples R China
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- Berglund, Björn (författare)
- Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Zhejiang Univ, Peoples R China
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- Zou, Huiyun (författare)
- Shandong Univ, Peoples R China
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- Sun, Qiang (författare)
- Shandong Univ, Peoples R China
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- Chi, Xiaohui (författare)
- Shandong Univ, Peoples R China
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- Ottoson, Jakob (författare)
- Natl Food Agcy, Sweden
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- Li, Xuewen (författare)
- Shandong Univ, Peoples R China
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- Lundborg, Cecilia Stalsby (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Nilsson, Lennart E (författare)
- Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2019
- 2019
- Engelska.
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Ingår i: Environmental Pollution. - : ELSEVIER SCI LTD. - 0269-7491 .- 1873-6424. ; 251, s. 619-627
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Antibiotic resistance among gram-negative bacteria is increasingly becoming a problem of global concern. Particularly problematic is the emergence of resistance to last-resort antibiotics such as carbapenems and colistin. The increasing number of reports on the plasmid-mediated colistin resistance gene mcr-1 in isolates worldwide is raising concerns for the future usefulness of this class of antibiotics. Dissemination of mcr-1 is believed to have originated mainly from animal breeding, however, the role of the environment as a transmission source is not yet fully understood. In the current study, 89 extended spectrum beta-lactamase-producing Escherichia coli isolated from 231 samples from different environmental sources in 12 villages in a rural area of Shandong, China, were screened for mcr-1.17 (19.1%) mcr-1-positive isolates were found from different environmental sources, aggregated in 6 villages. Plasmids of three different Inc-groups carrying mcr-1 were confirmed, indicating that the widespread geographical distribution of mcr-1 in the local area is due to a number of different plasmids. Additionally, almost a third (29.4%) of the isolates carried virulence factors associated to intestinal pathogenic E. coli. These results illustrate the high complexity of the transmission patterns of mcr-1 among different environmental matrices on a local scale and the potential for the environment to facilitate dissemination and emergence of antibiotic-resistant and virulent strains of bacteria. (C) 2019 Elsevier Ltd. All rights reserved.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Escherichia coli; mcr-1; Environment; Virulence factors; Whole-genome sequencing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Ji, Xiang
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Zheng, Beiwen
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Berglund, Björn
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Zou, Huiyun
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Sun, Qiang
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Chi, Xiaohui
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visa fler...
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Ottoson, Jakob
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Li, Xuewen
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Lundborg, Cecili ...
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Nilsson, Lennart ...
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Linköpings universitet
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