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Antibodies to oxidi...
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Strollo, RockyUniv Campus Biomed Roma, Italy
(författare)
Antibodies to oxidized insulin improve prediction of type 1 diabetes in children with positive standard islet autoantibodies
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-02-18
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John Wiley & Sons,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-159595
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159595URI
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https://doi.org/10.1002/dmrr.3132DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|EFSD/JDRF/Lilly European Programme in Type 1 Diabetes Research [3-PAR-2016-277-A-N]; JDRF [INO-2015-78-S-B, 1-SRA-2017-512-Q-R]; EFSD Future Leaders Mentorship Programme; Swedish Research Council [K2005-72X-11242-11A, K2008-69X-20826-01-4]; Swedish Child Diabetes Foundation (Barndiabetesfonden); JDRF Wallenberg Foundation [K 98-99D-12813-01A]; Medical Research Council of Southeast Sweden (FORSS); Swedish Council for Working Life and Social Research [FAS2004-1775]
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BackgroundAntibodies to posttranslationally modified insulin (oxPTM‐INS‐Ab) are a novel biomarker of type 1 diabetes (T1D). Here, we evaluated whether oxPTM‐INS‐Ab can improve T1D prediction in children with positive standard islet autoantibodies (AAB).MethodsWe evaluated sensitivity, specificity, accuracy, and risk for progression to T1D associated with oxPTM‐INS‐Ab and the standard islet AAB that include insulin (IAA), GAD (GADA), and tyrosine phosphatase 2 (IA‐2A) in a cohort of islet AAB‐positive (AAB+) children from the general population (median follow‐up 8.8 years).ResultsoxPTM‐INS‐Ab was the most sensitive and specific autoantibody biomarker (74% sensitivity, 91% specificity), followed by IA‐2A (71% sensitivity, 91% specificity). GADA and IAA showed lower sensitivity (65% and 50%, respectively) and specificity (66% and 68%, respectively). Accuracy (AUC of ROC) of oxPTM‐INS‐Ab was higher than GADA and IAA (P = 0.003 and P = 0.017, respectively), and similar to IA‐2A (P = 0.896). oxPTM‐INS‐Ab and IA‐2A were more effective than IAA for detecting progr‐T1D when used as second‐line biomarker in GADA+ children. Risk for diabetes was higher (P = 0.03) among multiple AAB+ who were also oxPTM‐INS‐Ab+ compared with those who were oxPTM‐INS‐Ab–. Importantly, when replacing IAA with oxPTM‐INS‐Ab, diabetes risk increased to 100% in children with oxPTM‐INS‐Ab+ in combination with GADA+ and IA‐2A+, compared with 84.37% in those with IAA+, GADA+, and IA‐2A+ (P = 0.04).ConclusionsAntibodies to oxidized insulin (oxPTM‐INS‐Ab), compared with IAA which measure autoantibodies to native insulin, improve T1D risk assessment and prediction accuracy in AAB+ children.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Vinci, ChiaraUniv Campus Biomed Roma, Italy; Queen Mary Univ London, England
(författare)
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Napoli, NicolaUniv Campus Biomed Roma, Italy; IRCCS Ist Ortoped Galeazzi, Italy
(författare)
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Fioriti, ElviraUniv Campus Biomed Roma, Italy
(författare)
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Maddaloni, ErnestoUniv Campus Biomed Roma, Italy
(författare)
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Åkerman, LindaLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)linak20
(författare)
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Casas, RosauraLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten(Swepub:liu)rosca56
(författare)
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Pozzilli, PaoloUniv Campus Biomed Roma, Italy; Queen Mary Univ London, England
(författare)
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Ludvigsson, JohnnyLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus(Swepub:liu)johlu29
(författare)
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Nissim, AhuvaQueen Mary Univ London, England
(författare)
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Univ Campus Biomed Roma, ItalyUniv Campus Biomed Roma, Italy; Queen Mary Univ London, England
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes/Metabolism Research Reviews: John Wiley & Sons35:41520-75521520-7560
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Strollo, Rocky
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Vinci, Chiara
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Napoli, Nicola
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Fioriti, Elvira
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Maddaloni, Ernes ...
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Åkerman, Linda
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visa fler...
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Casas, Rosaura
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Pozzilli, Paolo
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Ludvigsson, John ...
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Nissim, Ahuva
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