Search: WFRF:(Tisell Anders 1981 )
> (2015-2019) >
Reduced excitatory ...
-
Bednarska, Olga,1973-Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
(author)
Reduced excitatory neurotransmitter levels in anterior insulae are associated with abdominal pain in irritable bowel syndrome
- Article/chapterEnglish2019
Publisher, publication year, extent ...
-
Lippincott Williams & Wilkins,2019
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-160012
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160012URI
-
https://doi.org/10.1097/j.pain.0000000000001589DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Funding agencies: NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P41-RR14075, R01 RR16594-01A1, R01 NS052585-01, K08 MH01573, K01 MH01798]; County Council of Ostergotland; AFA research foundation [DNR. 140407]; Bengt-Ihre f
-
Irritable bowel syndrome (IBS) is a visceral pain condition with psychological comorbidity. Brain imaging studies in IBS demonstratealtered function in anterior insula (aINS), a key hub for integration of interoceptive, affective, and cognitive processes. However,alterations in aINS excitatory and inhibitory neurotransmission as putative biochemical underpinnings of these functional changesremain elusive. Using quantitative magnetic resonance spectroscopy, we compared women with IBS and healthy women (healthycontrols [HC]) with respect to aINS glutamate 1 glutamine (Glx) and g-aminobutyric acid (GABA1) concentrations and addressedpossible associations with symptoms. Thirty-nine women with IBS and 21 HC underwent quantitative magnetic resonancespectroscopy of bilateral aINS to assess Glx and GABA1 concentrations. Questionnaire data from all participants and prospectivesymptom-diary data from patients were obtained for regression analyses of neurotransmitter concentrations with IBS-related andpsychological parameters. Concentrations of Glx were lower in IBS compared with HC (left aINS P , 0.05, right aINS P , 0.001),whereas no group differences were detected for GABA1concentrations. Lower right-lateralized Glx concentrations in patients weresubstantially predicted by longer pain duration, while less frequent use of adaptive pain‐coping predicted lower Glx in left aINS. Ourfindings provide first evidence for reduced excitatory but unaltered inhibitory neurotransmitter levels in aINS in IBS. The results alsoindicate a functional lateralization of aINS with a stronger involvement of the right hemisphere in perception of abdominal pain and ofthe left aINS in cognitive pain regulation. Our findings suggest that glutaminergic deficiency may play a role in pain processing in IBS.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Icenhour, AdrianeLinköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Avdelningen för neuro- och inflammationsvetenskap,Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany(Swepub:liu)adric00
(author)
-
Tapper, Sofie,1989-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)softa96
(author)
-
Witt, Suzanne Tyson,1979-Linköpings universitet,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)suzwi54
(author)
-
Tisell, Anders,1981-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik(Swepub:liu)andti51
(author)
-
Lundberg, Peter,1958-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik(Swepub:liu)petlu11
(author)
-
Elsenbruch, SigridInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
(author)
-
Engström, Maria,1958-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)maren21
(author)
-
Walter, Susanna,1969-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Magtarmmedicinska kliniken(Swepub:liu)suswa35
(author)
-
Linköpings universitetAvdelningen för Kirurgi, Ortopedi och Onkologi
(creator_code:org_t)
Related titles
-
In:Pain: Lippincott Williams & Wilkins160:9, s. 2004-20120304-39591872-6623
Internet link
Find in a library
-
Pain
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Bednarska, Olga, ...
-
Icenhour, Adrian ...
-
Tapper, Sofie, 1 ...
-
Witt, Suzanne Ty ...
-
Tisell, Anders, ...
-
Lundberg, Peter, ...
-
show more...
-
Elsenbruch, Sigr ...
-
Engström, Maria, ...
-
Walter, Susanna, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Radiology Nuclea ...
- Articles in the publication
-
Pain
- By the university
-
Linköping University