id:"swepub:oai:DiVA.org:liu-160751"
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- Alonso, Fabiola,1980-Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Neuroengineering (författare)
Influence of Virchow-Robin spaces in the Electric Field Distribution in Subthalamic Nucleus Deep Brain Stimulation
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
- S. Karger,2019
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-160751
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160751URI
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- Språk:engelska
- Sammanfattning på:engelska
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- Objectives: Previous investigations have shown the appearance of cysts i.e. Virchow-Robin spaces (VR) in the basal ganglia and their relationship with parkinsonian symptoms [1-3]. Simulations [4]using the finite element method (FEM) suggests that VR affects the electric field around deep brain stimulation (DBS) electrodes. The aim of the study was to evaluate how the electric field is modified by the presence of cysts in the STN. Methods: The effect of cysts on the electric field around the DBS lead placed in the STN was evaluated using FEM. 3D patient-specific brain models were built with COMSOL 5.2 (COMSOL AB, Sweden) and an in-house developed software [5] to convert a T2 weighted MRI of Parkinsonian patients (ethics approval no: 2012/434-3) into electrical conductivity matrix readable by FEM software. VR was classified as CSF [6]assigning a high electrical conductivity (2.0 S/m). The stimulation amplitudes were set to the clinically programmed values. Depending on the lead used, the stimulation was set to voltage control (3389) or current control (6180, ring mode). The coordinates corresponding to the lowest (first) electrode and the third higher up in the lead, taken from the postoperative CT electrode artefact, were used to localize the leads in the brain model [7]. The electric field was visualized with a 0.2V/mm isosurface. Results: Simulations showed that the electric field distribution is affected by the cysts. The higher conductivity at these regions in the vicinity of the electrode redistributes the electric field pushing it away from the cyst. The same effect occurs regardless of the operating mode or the lead design as long as the directional lead is configured in ring mode. Conclusions: The use of patient-specific models has shown the importance of considering nuances of the patients’ anatomy in the STN. This information can be used to determine the stimulation parameter and to support the analysis of side effects induced by the stimulation. The potential advantage of directional leads can also be assessed by including in the model patient-specific data.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Zsigmond, Peter,1966-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Region Östergötland, Neurokirurgiska kliniken US(Swepub:liu)petzs86 (författare)
- Wårdell, Karin,1959-Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten(Swepub:liu)karwa46 (författare)
- Linköpings universitetAvdelningen för medicinsk teknik (creator_code:org_t)
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