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Pilot study on long...
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Covarrubias, YeseniaUniv Calif San Diego, CA 92093 USA
(author)
Pilot study on longitudinal change in pancreatic proton density fat fraction during a weight-loss surgery program in adults with obesity
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-30
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WILEY,2019
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LIBRIS-ID:oai:DiVA.org:liu-161004
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-161004URI
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https://doi.org/10.1002/jmri.26671DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 DK100651, K24 DK102595, R01 DK088925, R01 DK083380]; GE HealthcareGE Healthcare; PfizerPfizer; University of Wisconsin-Madison Office of the Vice Chancellor for Research and Graduate Education; Wisconsin Alumni Research Foundation
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Background Quantitative-chemical-shift-encoded (CSE)-MRI methods have been applied to the liver. The feasibility and potential utility CSE-MRI in monitoring changes in pancreatic proton density fat fraction (PDFF) have not yet been demonstrated. Purpose To use quantitative CSE-MRI to estimate pancreatic fat changes during a weight-loss program in adults with severe obesity and nonalcoholic fatty liver disease (NAFLD). To explore the relationship of reduction in pancreatic PDFF with reductions in anthropometric indices. Study Type Prospective/longitudinal. Population Nine adults with severe obesity and NAFLD enrolled in a weight-loss program. Field Strength/Sequence CSE-MRI fat quantification techniques and multistation-volumetric fat/water separation techniques were performed at 3 T. Assessment PDFF values were recorded from parametric maps colocalized across timepoints. Statistical Tests Rates of change of log-transformed variables across time were determined (linear-regression), and their significance assessed compared with no change (Wilcoxon test). Rates of change were correlated pairwise (Spearmans correlation). Results Mean pancreatic PDFF decreased by 5.7% (range 0.7-17.7%) from 14.3 to 8.6%, hepatic PDFF by 11.4% (2.6-22.0%) from 14.8 to 3.4%, weight by 30.9 kg (17.3-64.2 kg) from 119.0 to 88.1 kg, body mass index by 11.0 kg/m(2) (6.3-19.1 kg/m(2)) from 44.1 to 32.9 kg/m(2), waist circumference (WC) by 25.2 cm (4.0-41.0 cm) from 133.1 to 107.9 cm, HC by 23.5 cm (4.5-47.0 cm) from 135.8 to 112.3 cm, visceral adipose tissue (VAT) by 2.9 L (1.7-5.7 L) from 7.1 to 4.2 L, subcutaneous adipose tissue (SCAT) by 4.0 L (2.9-7.4 L) from 15.0 to 11.0 L. Log-transformed rate of change for pancreatic PDFF was moderately correlated with log-transformed rates for hepatic PDFF, VAT, SCAT, and WC (rho = 0.5, 0.47, 0.45, and 0.48, respectively), although not statistically significant. Data Conclusion Changes in pancreatic PDFF can be estimated by quantitative CSE-MRI in adults undergoing a weight-loss surgery program. Pancreatic and hepatic PDFF and anthropometric indices decreased significantly. Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1092-1102.
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Fowler, Kathryn J.Univ Calif San Diego, CA 92093 USA
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Mamidipalli, AdrijaUniv Calif San Diego, CA 92093 USA
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Hamilton, GavinUniv Calif San Diego, CA 92093 USA
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Wolfson, TanyaUniv Calif San Diego, CA 92093 USA
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Dahlqvist Leinhard, Olof,1978-Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Radiofysikavdelningen US,AMRA Med AB, Linkoping, Sweden(Swepub:liu)oloda24
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Jacobsen, GarthUniv Calif San Diego, CA 92093 USA
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Horgan, SantiagoUniv Calif San Diego, CA 92093 USA
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Schwimmer, Jeffrey B.Univ Calif San Diego, CA 92093 USA; Rady Childrens Hosp San Diego, CA USA
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Reeder, Scott B.Univ Wisconsin, WI 53706 USA; Univ Wisconsin, WI 53706 USA; Univ Wisconsin, WI USA; Univ Wisconsin, WI USA
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Sirlin, Claude B.Univ Calif San Diego, CA 92093 USA
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Univ Calif San Diego, CA 92093 USAAvdelningen för radiologiska vetenskaper
(creator_code:org_t)
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In:Journal of Magnetic Resonance Imaging: WILEY50:4, s. 1092-11021053-18071522-2586
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