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  • Bakhtadze, EkaterineLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups (author)

Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2008-10-07
  • Springer Science and Business Media LLC,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-16119
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16119URI
  • https://doi.org/10.1007/s00125-008-1161-2DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19472URI
  • https://lup.lub.lu.se/record/1262538URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211251URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117821177URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diabetes in young (15-34 years) and middle-aged (40-59 years) diabetic patients. In 1,642 young and 1,619 middle-aged patients we determined: (1) HLA-DQB1 genotypes; (2) PTPN22 and INS variable-number tandem repeat (VNTR) polymorphisms; (3) two single nucleotide polymorphisms (rs7903146 and rs10885406) in the TCF7L2 gene; (4) glutamic acid decarboxylase (GAD) and IA-2-protein tyrosine phosphatase-like protein (IA-2) antibodies; and (5) fasting plasma C-peptide. Frequency of risk genotypes HLA-DQB1 (60% vs 25%, p =9.4x10(-34); 45% vs 18%, p= 1.4x10(-16)), PTPN22 CT/TT (34% vs 26%, p=0.0023; 31% vs 23%, p=0.034), INS VNTR class I/I (69% vs 53%, p=1.3x10(-8); 69% vs 51%, p=8.5x10(-5)) and INS VNTR class IIIA/IIIA (75% vs 63%, p=4.3x10(-6); 73% vs 60%, p=0.008) was increased in young and middle-aged GAD antibodies (GADA)-positive compared with GADA-negative patients. The type 2 diabetes-associated genotypes of TCF7L2 CT/TT of rs7903146 were significantly more common in young GADA-negative than in GADA-positive patients (53% vs 43%; p=0.0004). No such difference was seen in middle-aged patients, in whom the frequency of the CT/TT genotypes of TCF7L2 was similarly increased in GADA-negative and GADA-positive groups (55% vs 56%). Common variants in the TCF7L2 gene help to differentiate young but not middle-aged GADA-positive and GADA-negative diabetic patients, suggesting that young GADA-negative patients have type 2 diabetes and that middle-aged GADA-positive patients are different from their young GADA-positive counterparts and share genetic features with type 2 diabetes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cervin, CamillaLund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups,Lund University Hospital(Swepub:lu)endo-cce (author)
  • Lindholm, EeroLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-eli (author)
  • Borg, HenrikLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för kliniska vetenskaper, Malmö,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Malmö(Swepub:lu)endo-hbo (author)
  • Nilsson, PLund University (author)
  • Arnqvist, HansLinköpings universitet,Hälsouniversitetet,Cellbiologi,Landstinget i Östergötland; Local Health Care Services in Central Östergötland; Department of Endocrinology and Gastroenterology; Närsjukvården i centrala Östergötland; Endokrin- och magtarmmedicinska kliniken(Swepub:liu)hanar64 (author)
  • Bolinder, JKarolinska Institutet,Karolinska University (author)
  • Eriksson, Jan WUmeå universitet,Medicin,Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden,Umeå University Hospital(Swepub:uu)janer909 (author)
  • Gudbjornsdottir, SSahlgrens University Hospital,Lund University Hospital (author)
  • Nyström, LennarthUmeå universitet,Epidemiologi och folkhälsovetenskap,Umeå University Hospital(Swepub:umu)leny0002 (author)
  • Agardh, C DLund University (author)
  • Landin-Olsson, MonaLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital(Swepub:lu)med-mla (author)
  • Sundkvist, GöranLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-gsu (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC51:12, s. 2224-22320012-186X1432-0428

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