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Sökning: id:"swepub:oai:DiVA.org:liu-16134" > Increased circulati...

  • Persson, MarieLinköpings universitet,Klinisk immunologi,Hälsouniversitetet (författare)

Increased circulating paternal antigen-specific IFN-γ- and IL-4-secreting cells during pregnancy in allergic and non-allergic women

  • Artikel/kapitelEngelska2008

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2008
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-16134
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16134URI
  • https://doi.org/10.1016/j.jri.2008.07.001DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • INTRODUCTION: Allergic women have been reported to give birth to more children than non-allergic women, speculatively explained by the former's predisposition for Th2 polarization, possibly favoring pregnancy.AIM: The aim of this study was to test the hypothesis that allergy is associated with more Th2-deviated responses to paternal antigens throughout pregnancy.METHODS: Blood samples were collected on six occasions during pregnancy and two occasions postpartum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Eleven women fulfilled the strict criteria for allergy (allergic symptoms and circulating IgE antibodies to inhalant allergens) and 23 were strictly non-allergic (non-sensitized without symptoms). The numbers of blood mononuclear cells secreting IFN-gamma and IL-4, spontaneously and in response to paternal alloantigens, were compared between the groups.RESULTS: The numbers of spontaneously as well as paternal antigen-induced IFN-gamma- and IL-4-secreting cells were similar in allergic and non-allergic pregnant women on all occasions. A similar increase in the numbers of both IFN-gamma- and IL-4-secreting cells were found in allergic and non-allergic women during pregnancy, both regarding spontaneous and paternal antigen-induced secretion.CONCLUSIONS: This study does not support the hypothesis of a more pronounced Th2-deviation to paternal antigens in allergic pregnant women compared with non-allergic pregnant women, as measured by number of cytokine-secreting cells. The observed increase of both IFN-gamma- and IL-4-secreting cells during normal pregnancy may be interpreted as a Th2-situation, since the effects of IL-4 predominate over the effects of IFN-gamma.

Ämnesord och genrebeteckningar

  • Pregnancy
  • Th2
  • Elispot
  • MLC
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ekerfelt, ChristinaLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)chrek55 (författare)
  • Ernerudh, JanLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)janer15 (författare)
  • Matthiesen, LeifÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Kvinnokliniken i Linköping,Hälsouniversitetet(Swepub:liu)leima96 (författare)
  • Jenmalm, MariaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marje18 (författare)
  • Jonsson, YvonneLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)yvojo35 (författare)
  • Sandberg, MartinaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marsa92 (författare)
  • Berg, GöranÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Kvinnokliniken i Linköping,Hälsouniversitetet(Swepub:liu)gorbe09 (författare)
  • Linköpings universitetKlinisk immunologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Reproductive Immunology: Elsevier BV79:1, s. 70-780165-03781872-7603

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