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Resurgent Na+ Curre...
Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons.
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- Venugopal, Sharmila (författare)
- Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, United States of America
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- Seki, Soju (författare)
- Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, United States of America
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- Terman, David H. (författare)
- Department of Mathematics, The Ohio State University, Columbus, OH, United States of America
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- Pantazis, Antonios, 1982- (författare)
- Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten,Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America
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- Olcese, Riccardo (författare)
- Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America
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- Wiedau-Pazos, Martina (författare)
- Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America
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- Chandler, Scott H. (författare)
- Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, United States of America
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(creator_code:org_t)
- 2019-06-21
- 2019
- Engelska.
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Ingår i: PloS Computational Biology. - : PLOS. - 1553-734X .- 1553-7358. ; 15:6
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Neurons utilize bursts of action potentials as an efficient and reliable way to encode information. It is likely that the intrinsic membrane properties of neurons involved in burst generation may also participate in preserving its temporal features. Here we examined the contribution of the persistent and resurgent components of voltage-gated Na+ currents in modulating the burst discharge in sensory neurons. Using mathematical modeling, theory and dynamic-clamp electrophysiology, we show that, distinct from the persistent Na+ component which is important for membrane resonance and burst generation, the resurgent Na+ can help stabilize burst timing features including the duration and intervals. Moreover, such a physiological role for the resurgent Na+ offered noise tolerance and preserved the regularity of burst patterns. Model analysis further predicted a negative feedback loop between the persistent and resurgent gating variables which mediate such gain in burst stability. These results highlight a novel role for the voltage-gated resurgent Na+ component in moderating the entropy of burst-encoded neural information.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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