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Benchmarking biomar...
Benchmarking biomarker-based criteria for Alzheimer's disease : Data from the Swedish Dementia Registry, SveDem.
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- Rosén, Christoffer, 1986 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
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- Farahmand, Bahman (author)
- Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Huddinge, Sweden
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- Skillbäck, Tobias (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
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- Nägga, Katarina (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Malmö, Sweden
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- Mattsson, Niklas, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; University of California San Francisco, San Francisco, CA, USA
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik,Uppsala University, Uppsala, Sweden
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- Religa, Dorota (author)
- Karolinska Institutet,Karolinska University Hospital, Huddinge, Sweden; Karolinska Institutet, Huddinge, Sweden
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- Wimo, Anders (author)
- Karolinska Institutet,Karolinska Institutet, Huddinge, Sweden
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
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- Winblad, Bengt (author)
- Karolinska Institutet,Karolinska University Hospital, Huddinge, Sweden; Karolinska Institutet, Huddinge, Sweden
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology, London, UK
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- Eriksdotter, Maria (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Huddinge, Sweden
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(creator_code:org_t)
- 2015-06-13
- 2015
- English.
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In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 11:12, s. 1470-1479
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- INTRODUCTION: New research guidelines for the diagnosis of Alzheimer's disease (AD) include biomarker evidence of amyloid-β (Aβ) and tau pathology. The aim of this study was to investigate what proportion of AD patients diagnosed in clinical routine in Sweden that had an AD-indicative cerebrospinal fluid (CSF) biomarker profile.METHODS: By cross-referencing a laboratory database with the Swedish Dementia Registry (SveDem), 2357 patients with data on CSF Aβ and tau biomarkers and a clinical diagnosis of AD with dementia were acquired.RESULTS: Altogether, 77.2% had pathologic Aβ42 and total tau or phosphorylated tau in CSF. These results were stable across age groups. Female sex and low mini-mental state examination score increased the likelihood of pathologic biomarkers.DISCUSSION: About a quarter of clinically diagnosed AD patients did not have an AD-indicative CSF biomarker profile. This discrepancy may partly reflect incorrect (false positive) clinical diagnosis or a lack in sensitivity of the biomarker assays.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Biomarkers
- Cerebrospinal fluid
- Diagnosis
- Diagnostic criteria
- Alzheimer's disease; Diagnostic criteria; Diagnosis; Cerebrospinal fluid; Biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rosén, Christoff ...
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Farahmand, Bahma ...
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Skillbäck, Tobia ...
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Nägga, Katarina
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Mattsson, Niklas ...
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Kilander, Lena
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Religa, Dorota
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Wimo, Anders
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Blennow, Kaj, 19 ...
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Winblad, Bengt
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Zetterberg, Henr ...
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Eriksdotter, Mar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Linköping University
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Lund University
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Karolinska Institutet
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Uppsala University
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University of Gothenburg