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  • Hayden, Patrick J.St James Hosp, Ireland (author)

Conditioning-based outcomes after allogeneic transplantation for myeloma following a prior autologous transplant (1991-2012) on behalf of EBMT CMWP

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • WILEY,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-163031
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163031URI
  • https://doi.org/10.1111/ejh.13352DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objectives The aim of this study was to compare the effect of the intensity of conditioning approaches used in allogeneic transplantation in myeloma-reduced intensity conditioning (RIC), non-myeloablative (NMA), myeloablative conditioning (MAC) or Auto-AlloHCT-on outcomes in patients who had had a prior autologous transplant. Methods A retrospective analysis of the EBMT database (1991-2012) was performed. Results A total of 344 patients aged between 40 and 60 years at the time of alloHCT were identified: 169 RIC, 69 NMA, 65 MAC and 41 Auto-Allo transplants. At a median follow-up of 54 months, the probabilities of overall survival (OS) at 5 years were 39% (95% CI 31%-47%), 45% (95% CI 32%-57%), 19% (95% CI 6%-32%) and 34% (95% CI 17%-51%), respectively. Status at allogeneic HCT other than CR or PR conferred a 70% higher risk of death and a 40% higher risk of relapse. OS was markedly lower in the MAC group (P = .004). MAC alloHCT was associated with a higher risk of death than RIC alloHCT until 2002 (HR = 4.1, P amp;lt; .001) but not after 2002 (HR = 1.2, P = .276). Conclusion From 1991 to 2002, MAC was associated with poorer OS. Between 2003 and 2012, there were no significant differences in outcomes based on these different approaches.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Iacobelli, SimonaTor Vergata Univ Rome, Italy (author)
  • Antonio Perez-Simon, JoseHosp Univ Virgen Rocio, Spain; Univ Seville, Spain (author)
  • van Biezen, AnjaLeiden EBMT Data Off, Netherlands (author)
  • Minnema, MoniqueUniv Med Ctr Utrecht, Netherlands (author)
  • Niittyvuopio, RiittaHUCH Comprehens Canc Ctr, Finland (author)
  • Schoenland, StefanHeidelberg Univ, Germany (author)
  • Meijer, EllenVrije Univ Amsterdam Med Ctr, Netherlands (author)
  • Blaise, DidierMarseille Inst Paoli Calmettes, France (author)
  • Milpied, NoelCHU Bordeaux, France (author)
  • Marquez-Malaver, Francisco J.Hosp Univ Virgen Rocio, Spain; Univ Seville, Spain (author)
  • Veelken, Joan HendrikLeiden Univ, Netherlands (author)
  • Maertens, JohanUniv Hosp Gasthuisberg, Belgium (author)
  • Michallet, MauricetteCtr Hosp Lyon Sud, France (author)
  • Cammenga, JörgLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US(Swepub:liu)jorca02 (author)
  • NGuyen, StephanieHop La Pitie Salpetriere, France (author)
  • Niederwieser, DietgerUniv Hosp Leipzig, Germany (author)
  • Hunault-Berger, MathildeCHRU Angers, France (author)
  • Bourhis, Jean HenriGustave Roussy Inst Cancerol, France (author)
  • Passweg, JakobUniv Hosp Basel, Switzerland (author)
  • Bermudez, AranchaFEA Serv Hematol, Spain (author)
  • Chalandon, YvesHop Univ Geneve, Switzerland; Univ Geneva, Switzerland (author)
  • Yakoub-Agha, IbrahimHop Claude Huriez, France (author)
  • Garderet, LaurentHosp St Antoine, France (author)
  • Kroeger, NicolausUniv Hosp Eppendorf, Germany (author)
  • St James Hosp, IrelandTor Vergata Univ Rome, Italy (creator_code:org_t)

Related titles

  • In:European Journal of Haematology: WILEY0902-44411600-0609

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