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Staging of Schizoph...
Staging of Schizophrenia With the Use of PANSS : An International Multi-Center Study
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- Fountoulakis, Konstantinos N. (author)
- Aristotle Univ Thessaloniki, Greece
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- Dragioti, Elena, Ph.D. (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden
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- Theofilidis, Antonis T. (author)
- Aristotle Univ Thessaloniki, Greece
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- Wiklund, Tobias, 1986- (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden
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- Atmatzidis, Xenofon (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Karolinska Huddinge Univ Hosp, Sweden
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- Nimatoudis, Ioannis (author)
- Aristotle Univ Thessaloniki, Greece
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- Thys, Erik (author)
- Katholieke Univ Leuven, Belgium; KU, Belgium
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- Wampers, Martien (author)
- Katholieke Univ Leuven, Belgium; KU, Belgium
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- Hranov, Luchezar (author)
- Univ Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria
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- Hristova, Trayana (author)
- Univ Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria
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- Aptalidis, Daniil (author)
- Univ Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria
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- Milev, Roumen (author)
- Queens Univ, Canada
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- Iftene, Felicia (author)
- Queens Univ, Canada
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- Spaniel, Filip (author)
- Natl Inst Mental Hlth, Czech Republic
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- Knytl, Pavel (author)
- Natl Inst Mental Hlth, Czech Republic
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- Furstova, Petra (author)
- Natl Inst Mental Hlth, Czech Republic
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- From, Tiina (author)
- Univ Turku, Finland
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- Karlsson, Henry (author)
- Univ Turku, Finland
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- Walta, Maija (author)
- Univ Turku, Finland
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- Salokangas, Raimo K. R. (author)
- Univ Turku, Finland
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- Azorin, Jean-Michel (author)
- St Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France
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- Bouniard, Justine (author)
- St Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France
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- Montant, Julie (author)
- St Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France
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- Juckel, Georg (author)
- Ruhr Univ Bochum, Germany
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- Haussleiter, Ida S. (author)
- Ruhr Univ Bochum, Germany
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- Douzenis, Athanasios (author)
- Univ Athens, Greece
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- Michopoulos, Ioannis (author)
- Univ Athens, Greece
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- Ferentinos, Panagiotis (author)
- Univ Athens, Greece
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- Smyrnis, Nikolaos (author)
- Univ Athens, Greece
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- Mantonakis, Leonidas (author)
- Univ Athens, Greece
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- Nemes, Zsofia (author)
- Nyiro Gyula Hosp, Hungary
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- Gonda, Xenia (author)
- Semmelweis Univ, Hungary
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- Vajda, Dora (author)
- Semmelweis Univ, Hungary
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- Juhasz, Anita (author)
- Semmelweis Univ, Hungary
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- Shrivastava, Amresh (author)
- Western Univ, Canada
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- Waddington, John (author)
- Royal Coll Surgeons Ireland, Ireland
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- Pompili, Maurizio (author)
- Sapienza Univ Rome, Italy
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- Comparelli, Anna (author)
- Sapienza Univ Rome, Italy
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- Corigliano, Valentina (author)
- Sapienza Univ Rome, Italy
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- Rancans, Elmars (author)
- Riga Stradins Univ, Latvia
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- Navickas, Alvydas (author)
- Vilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania
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- Hilbig, Jan (author)
- Vilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania
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- Bukelskis, Laurynas (author)
- Vilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania
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- Stevovic, Lidija Injac (author)
- Clin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro
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- Vodopic, Sanja (author)
- Clin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro
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- Esan, Oluyomi (author)
- Univ Ibadan, Nigeria
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- Oladele, Oluremi (author)
- Univ Ibadan, Nigeria
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- Osunbote, Christopher (author)
- Univ Ibadan, Nigeria
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- Rybakowski, Janusz K. (author)
- Poznan Univ Med Sci, Poland
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- Wojciak, Pawel (author)
- Poznan Univ Med Sci, Poland
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- Domowicz, Klaudia (author)
- Poznan Univ Med Sci, Poland
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- Figueira, Maria Luisa (author)
- Santa Maria Univ Hosp, Portugal
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- Linhares, Ludgero (author)
- Santa Maria Univ Hosp, Portugal
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- Crawford, Joana (author)
- Santa Maria Univ Hosp, Portugal
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- Panfil, Anca-Livia (author)
- Univ Med and Pharm Targu Mures, Romania
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- Smirnova, Daria (author)
- Samara State Med Univ, Russia
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- Izmailova, Olga (author)
- Samara State Med Univ, Russia
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- Lecic-Tosevski, Dusica (author)
- Inst Mental Hlth, Serbia; Serbian Acad Arts and Sci, Serbia
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- Temmingh, Henk (author)
- Univ Cape Town, South Africa
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- Howells, Fleur (author)
- Univ Cape Town, South Africa
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- Bobes, Julio (author)
- Univ Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain
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- Garcia-Portilla, Maria Paz (author)
- Univ Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain
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- Garcia-Alvarez, Leticia (author)
- Univ Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain
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- Erzin, Gamze (author)
- Diskapi Yildirim Beyazit Training and Res Hosp, Turkey
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- Karadag, Hasan (author)
- Diskapi Yildirim Beyazit Training and Res Hosp, Turkey
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- De Sousa, Avinash (author)
- Lokmanya Tilak Municipal Gen Hosp and Med Coll, India
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- Bendre, Anuja (author)
- Lokmanya Tilak Municipal Gen Hosp and Med Coll, India
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- Hoschl, Cyril (author)
- Natl Inst Mental Hlth, Czech Republic
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- Bredicean, Cristina (author)
- Univ Med and Farm Timisoara, Romania
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- Papava, Ion (author)
- Univ Med and Farm Timisoara, Romania
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- Vukovic, Olivera (author)
- Univ Belgrade, Serbia
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- Pejuskovic, Bojana (author)
- Royal Coll Surgeons Ireland, Ireland
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- Russell, Vincent (author)
- Royal Coll Surgeons Ireland, Ireland
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- Athanasiadis, Loukas (author)
- Aristotle Univ Thessaloniki, Greece
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- Konsta, Anastasia (author)
- Aristotle Univ Thessaloniki, Greece
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- Stein, Dan (author)
- Univ Cape Town, South Africa
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- Berk, Michael (author)
- Deakin Univ, Australia; Orygen, Australia; Univ Melbourne, Australia; Univ Melbourne, Australia; Univ Melbourne, Australia
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- Dean, Olivia (author)
- Deakin Univ, Australia
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- Tandon, Rajiv (author)
- Univ Florida, FL 32611 USA
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- Kasper, Siegfried (author)
- Med Univ Vienna, Austria
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- De Hert, Marc (author)
- Katholieke Univ Leuven, Belgium; KU, Belgium
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(creator_code:org_t)
- 2019-09-30
- 2019
- English.
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In: International Journal of Neuropsychopharmacology. - : Oxford University Press. - 1461-1457 .- 1469-5111. ; 22:11, s. 681-697
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- IntroductionA specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.MethodsTwenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.ResultsExploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.DiscussionThis study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- illness course; outcome; schizophrenia; staging
Publication and Content Type
- ref (subject category)
- art (subject category)
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Fountoulakis, Ko ...
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Dragioti, Elena, ...
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Theofilidis, Ant ...
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Wiklund, Tobias, ...
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Atmatzidis, Xeno ...
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Nimatoudis, Ioan ...
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Thys, Erik
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Wampers, Martien
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Hranov, Luchezar
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Hristova, Trayan ...
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Aptalidis, Danii ...
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Milev, Roumen
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Iftene, Felicia
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Spaniel, Filip
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Knytl, Pavel
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Furstova, Petra
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From, Tiina
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Karlsson, Henry
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Walta, Maija
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Salokangas, Raim ...
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Azorin, Jean-Mic ...
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Bouniard, Justin ...
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Montant, Julie
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Juckel, Georg
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Haussleiter, Ida ...
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Douzenis, Athana ...
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Michopoulos, Ioa ...
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Ferentinos, Pana ...
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Smyrnis, Nikolao ...
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Mantonakis, Leon ...
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Nemes, Zsofia
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Gonda, Xenia
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Vajda, Dora
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Juhasz, Anita
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Shrivastava, Amr ...
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Waddington, John
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Pompili, Maurizi ...
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Comparelli, Anna
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Corigliano, Vale ...
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Rancans, Elmars
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Navickas, Alvyda ...
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Hilbig, Jan
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Bukelskis, Laury ...
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Stevovic, Lidija ...
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Vodopic, Sanja
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Esan, Oluyomi
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Oladele, Oluremi
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Osunbote, Christ ...
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Rybakowski, Janu ...
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Wojciak, Pawel
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Domowicz, Klaudi ...
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Figueira, Maria ...
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Linhares, Ludger ...
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Crawford, Joana
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Panfil, Anca-Liv ...
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Smirnova, Daria
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Izmailova, Olga
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Lecic-Tosevski, ...
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Temmingh, Henk
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Howells, Fleur
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Bobes, Julio
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Garcia-Portilla, ...
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Garcia-Alvarez, ...
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Erzin, Gamze
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Karadag, Hasan
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De Sousa, Avinas ...
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Bendre, Anuja
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Hoschl, Cyril
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Bredicean, Crist ...
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Papava, Ion
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Vukovic, Olivera
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Pejuskovic, Boja ...
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Russell, Vincent
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Athanasiadis, Lo ...
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Konsta, Anastasi ...
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Stein, Dan
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Berk, Michael
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Dean, Olivia
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Tandon, Rajiv
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Kasper, Siegfrie ...
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De Hert, Marc
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Linköping University