Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study

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Fountoulakis, Konstantinos N.Aristotle Univ Thessaloniki, Greece (author)

Staging of Schizophrenia With the Use of PANSS : An International Multi-Center Study

Article/chapterEnglish2019

Publisher, publication year, extent ...

2019-09-30
Oxford University Press,2019
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-163483
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163483URI
https://doi.org/10.1093/ijnp/pyz053DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies|NHMRC Senior Principal Research FellowshipNational Health and Medical Research Council of Australia [APP1059660, APP1156072]
IntroductionA specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.MethodsTwenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.ResultsExploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.DiscussionThis study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
illness course; outcome; schizophrenia; staging

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Dragioti, Elena,Ph.D.Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden(Swepub:liu)eledr71 (author)
Theofilidis, Antonis T.Aristotle Univ Thessaloniki, Greece (author)
Wiklund, Tobias,1986-Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden(Swepub:liu)tobwi28 (author)
Atmatzidis, XenofonLinköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Karolinska Huddinge Univ Hosp, Sweden(Swepub:liu)n/a (author)
Nimatoudis, IoannisAristotle Univ Thessaloniki, Greece (author)
Thys, ErikKatholieke Univ Leuven, Belgium; KU, Belgium (author)
Wampers, MartienKatholieke Univ Leuven, Belgium; KU, Belgium (author)
Hranov, LuchezarUniv Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria (author)
Hristova, TrayanaUniv Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria (author)
Aptalidis, DaniilUniv Multiprofile Hosp Act Treatment Neurol and Psy, Bulgaria (author)
Milev, RoumenQueens Univ, Canada (author)
Iftene, FeliciaQueens Univ, Canada (author)
Spaniel, FilipNatl Inst Mental Hlth, Czech Republic (author)
Knytl, PavelNatl Inst Mental Hlth, Czech Republic (author)
Furstova, PetraNatl Inst Mental Hlth, Czech Republic (author)
From, TiinaUniv Turku, Finland (author)
Karlsson, HenryUniv Turku, Finland (author)
Walta, MaijaUniv Turku, Finland (author)
Salokangas, Raimo K. R.Univ Turku, Finland (author)
Azorin, Jean-MichelSt Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France (author)
Bouniard, JustineSt Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France (author)
Montant, JulieSt Marguerite Univ Hosp, France; CNRS, France; Aix Marseille Univ, France (author)
Juckel, GeorgRuhr Univ Bochum, Germany (author)
Haussleiter, Ida S.Ruhr Univ Bochum, Germany (author)
Douzenis, AthanasiosUniv Athens, Greece (author)
Michopoulos, IoannisUniv Athens, Greece (author)
Ferentinos, PanagiotisUniv Athens, Greece (author)
Smyrnis, NikolaosUniv Athens, Greece (author)
Mantonakis, LeonidasUniv Athens, Greece (author)
Nemes, ZsofiaNyiro Gyula Hosp, Hungary (author)
Gonda, XeniaSemmelweis Univ, Hungary (author)
Vajda, DoraSemmelweis Univ, Hungary (author)
Juhasz, AnitaSemmelweis Univ, Hungary (author)
Shrivastava, AmreshWestern Univ, Canada (author)
Waddington, JohnRoyal Coll Surgeons Ireland, Ireland (author)
Pompili, MaurizioSapienza Univ Rome, Italy (author)
Comparelli, AnnaSapienza Univ Rome, Italy (author)
Corigliano, ValentinaSapienza Univ Rome, Italy (author)
Rancans, ElmarsRiga Stradins Univ, Latvia (author)
Navickas, AlvydasVilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania (author)
Hilbig, JanVilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania (author)
Bukelskis, LaurynasVilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania (author)
Stevovic, Lidija InjacClin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro (author)
Vodopic, SanjaClin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro (author)
Esan, OluyomiUniv Ibadan, Nigeria (author)
Oladele, OluremiUniv Ibadan, Nigeria (author)
Osunbote, ChristopherUniv Ibadan, Nigeria (author)
Rybakowski, Janusz K.Poznan Univ Med Sci, Poland (author)
Wojciak, PawelPoznan Univ Med Sci, Poland (author)
Domowicz, KlaudiaPoznan Univ Med Sci, Poland (author)
Figueira, Maria LuisaSanta Maria Univ Hosp, Portugal (author)
Linhares, LudgeroSanta Maria Univ Hosp, Portugal (author)
Crawford, JoanaSanta Maria Univ Hosp, Portugal (author)
Panfil, Anca-LiviaUniv Med and Pharm Targu Mures, Romania (author)
Smirnova, DariaSamara State Med Univ, Russia (author)
Izmailova, OlgaSamara State Med Univ, Russia (author)
Lecic-Tosevski, DusicaInst Mental Hlth, Serbia; Serbian Acad Arts and Sci, Serbia (author)
Temmingh, HenkUniv Cape Town, South Africa (author)
Howells, FleurUniv Cape Town, South Africa (author)
Bobes, JulioUniv Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain (author)
Garcia-Portilla, Maria PazUniv Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain (author)
Garcia-Alvarez, LeticiaUniv Oviedo, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Spain (author)
Erzin, GamzeDiskapi Yildirim Beyazit Training and Res Hosp, Turkey (author)
Karadag, HasanDiskapi Yildirim Beyazit Training and Res Hosp, Turkey (author)
De Sousa, AvinashLokmanya Tilak Municipal Gen Hosp and Med Coll, India (author)
Bendre, AnujaLokmanya Tilak Municipal Gen Hosp and Med Coll, India (author)
Hoschl, CyrilNatl Inst Mental Hlth, Czech Republic (author)
Bredicean, CristinaUniv Med and Farm Timisoara, Romania (author)
Papava, IonUniv Med and Farm Timisoara, Romania (author)
Vukovic, OliveraUniv Belgrade, Serbia (author)
Pejuskovic, BojanaRoyal Coll Surgeons Ireland, Ireland (author)
Russell, VincentRoyal Coll Surgeons Ireland, Ireland (author)
Athanasiadis, LoukasAristotle Univ Thessaloniki, Greece (author)
Konsta, AnastasiaAristotle Univ Thessaloniki, Greece (author)
Stein, DanUniv Cape Town, South Africa (author)
Berk, MichaelDeakin Univ, Australia; Orygen, Australia; Univ Melbourne, Australia; Univ Melbourne, Australia; Univ Melbourne, Australia (author)
Dean, OliviaDeakin Univ, Australia (author)
Tandon, RajivUniv Florida, FL 32611 USA (author)
Kasper, SiegfriedMed Univ Vienna, Austria (author)
De Hert, MarcKatholieke Univ Leuven, Belgium; KU, Belgium (author)
Aristotle Univ Thessaloniki, GreeceAvdelningen för samhällsmedicin (creator_code:org_t)

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In:International Journal of Neuropsychopharmacology: Oxford University Press22:11, s. 681-6971461-14571469-5111

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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By the university: Linköping University

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