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Fecal microbiota pr...
Fecal microbiota profiles in treatment-naive pediatric inflammatory bowel disease : associations with disease phenotype, treatment, and outcome
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- Olbjern, Christine (author)
- Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Smastuen, Milada Cvancarova (author)
- Oslo Metropolitan Univ, Norway
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- Thiis-Evensen, Espen (author)
- Oslo Univ Hosp, Norway
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- Nakstad, Britt (author)
- Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Vatn, Morten Harald (author)
- Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Jahnsen, Jorgen (author)
- Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Ricanek, Pew (author)
- Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Vatn, Simen (author)
- Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Moen, Aina E. F. (author)
- Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Tannaes, Tone M. (author)
- Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Lindstrom, Jonas C. (author)
- Univ Oslo, Norway
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- Söderholm, Johan D, 1958- (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Halfvarson, Jonas, 1970- (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten
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- Gomollon, Fernando (author)
- IIS Aragon, Spain
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- Casen, Christina (author)
- Genet Anal AS, Norway
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- Karlsson, Magdalena K. (author)
- Genet Anal AS, Norway
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- Kalla, Rahul (author)
- Univ Edinburgh, Scotland
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- Adams, Alex T. (author)
- Univ Edinburgh, Scotland; Univ Oxford, England
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- Satsangi, Jack (author)
- Univ Edinburgh, Scotland; Univ Oxford, England
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- Perminow, Geri (author)
- Oslo Univ Hosp, Norway
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(creator_code:org_t)
- Macclesfield, United Kingdom : DOVE MEDICAL PRESS LTD, 2019
- 2019
- English.
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In: Clinical and Experimental Gastroenterology. - Macclesfield, United Kingdom : DOVE MEDICAL PRESS LTD. - 1178-7023. ; 12, s. 37-49
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- Purpose: Imbalance in the microbiota, dysbiosis, has been identified in inflammatory bowel disease (IBD). We explored the fecal microbiota in pediatric patients with treatment-naive IBD, non-IBD patients with gastrointestinal symptoms and healthy children, its relation to IBD subgroups, and treatment outcomes. Patients and methods: Fecal samples were collected from 235 children below 18 years of age. Eighty children had Crohns disease (CD), 27 ulcerative colitis (UC), 3 IBD unclassified, 50 were non-IBD symptomatic patients, and 75 were healthy. The bacterial abundance of 54 predefined DNA markers was measured with a 16S rRNA DNA-based test using GA-Map (TM) technology at diagnosis and after therapy in IBD patients. Results: Bacterial abundance was similarly reduced in IBD and non-IBD patients in 51 of 54 markers compared to healthy patients (Pamp;lt;0.001). Only Prevotella was more abundant in patients (Pamp;lt;0.01). IBD patients with ileocolitis or total colitis had more Ruminococcus gnavus (P=0.02) than patients with colonic CD or left-sided UC. CD patients with upper gastrointestinal manifestations had higher Veillonella abundance (Pamp;lt;0.01). IBD patients (58%) who received biologic therapy had lower baseline Firmicutes and Mycoplasma hominis abundance (Pamp;lt;0.01) than conventionally treated. High Proteobacteria abundance was associated with stricturing/penetrating CD, surgery (Pamp;lt;0.01), and nonmucosal healing (Pamp;lt;0.03). Low Faecalibacterium prausnitzii abundance was associated with prior antibiotic therapy (P=0.001), surgery (P=0.02), and nonmucosal healing (Pamp;lt;0.03). After therapy, IBD patients had unchanged dysbiosis. Conclusion: Fecal microbiota profiles differentiated IBD and non-IBD symptomatic children from healthy children, but displayed similar dysbiosis in IBD and non-IBD symptomatic patients. Pretreatment fecal microbiota profiles may be of prognostic value and aid in treatment individualization in pediatric IBD as severe dysbiosis was associated with an extensive, complicated phenotype, biologic therapy, and nonmucosal healing. The dysbiosis persisted after therapy, regardless of treatments and mucosal healing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- dysbiosis; Crohns disease; ulcerative colitis; Proteobacteria; biologic therapy; Faecalibacterium prausnitzii
Publication and Content Type
- ref (subject category)
- art (subject category)
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Olbjern, Christi ...
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Smastuen, Milada ...
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Thiis-Evensen, E ...
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Nakstad, Britt
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Vatn, Morten Har ...
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Jahnsen, Jorgen
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Ricanek, Pew
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Vatn, Simen
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Moen, Aina E. F.
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Tannaes, Tone M.
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Lindstrom, Jonas ...
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Söderholm, Johan ...
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Halfvarson, Jona ...
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Gomollon, Fernan ...
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Casen, Christina
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Karlsson, Magdal ...
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Kalla, Rahul
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Adams, Alex T.
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Satsangi, Jack
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Perminow, Geri
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Clinical and Exp ...
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Linköping University