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Genetic variations ...
Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis
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- Park, Jae Hyon (författare)
- Yonsei Univ, South Korea
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- Jeong, Gwang Hun (författare)
- Gyeongsang Natl Univ, South Korea
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- Lee, Kwang Seob (författare)
- Yonsei Univ, South Korea
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- Lee, Keum Hwa (författare)
- Severance Childrens Hosp, South Korea; Yonsei Univ, South Korea
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- Suh, Jin-Soon (författare)
- Catholic Univ Korea, South Korea
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- Eisenhut, Michael (författare)
- Luton and Dunstable Univ Hosp NHS Fdn Trust, England
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- Vliet, Hans J. van der (författare)
- Vrije Univ Amsterdam, Netherlands
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- Kronbichler, Andreas (författare)
- Med Univ Innsbruck, Austria
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- Stubbs, Brendon (författare)
- Kings Coll London, England; South London and Maudsley NHS Fdn Trust, England; Anglia Ruskin Univ, England
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- Solmi, Marco (författare)
- Univ Padua, Italy
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- Dragioti, Elena (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Koyanagi, Ai (författare)
- Univ Barcelona, Spain; ICREA, Spain
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- Shin, Jae Il (författare)
- Yonsei Univ, South Korea; Severance Childrens Hosp, South Korea; Yonsei Univ, South Korea
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- Gamerith, Gabriele (författare)
- Med Univ Innsbruck, Austria; Tyrolean Canc Res Inst, Austria
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(creator_code:org_t)
- WILEY, 2020
- 2020
- Engelska.
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Ingår i: European Journal of Clinical Investigation. - : WILEY. - 0014-2972 .- 1365-2362. ; 50:4
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. Method We searched PubMed and investigated the results of meta-analyses published through November 2018. We re-assessed the results based on false-positive report probability (FPRP) to test the noteworthiness of the associations. Results Sixty-eight miRNA polymorphisms in 45 meta-analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP < 0.2) at a prior probability of 0.001 for interesting candidate genes and a statistical power to detect an odds ratio (OR) of 1.1 and 1.5, respectively. The four miRNA SNPs noteworthy at an OR of 1.1 were as follows: miR-146a/rs2910164 Cvs.G; miR-27a/rs895819 Cvs.T; miR-423/rs6505162 Cvs.A; and miR-605/rs2043556 Cvs.T. The 16 SNPs noteworthy at an OR of 1.5 include the four genotype comparisons at an OR of 1.1, and the additional 12 genotype comparisons were as follows: miR-196a2/rs11614913 Tvs.C; miR-27a/rs895819 GGvs.AA + AG; miR-196a2/rs11614913 C vs.T; miR-146a/rs2910164 Gvs.C; miR-196a2/rs11614913 Tvs.C; miR-146a/rs2910164 Cvs.G; miR-499/rs3746444 homozygous model; miR-146a/rs2910164 CCvs.GG + GC; miR-499/rs3746444 TCvs.TT; miR-499/rs3746444 GAvs.AA; miR-146a/rs2910164 CCvs.GG; and miR-499/rs3746444 Gvs.A. No association was noteworthy at a prior probability of 0.000001. Conclusion Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re-assessing meta-analysis. Our findings summarize the results of meta-analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cancer; FPRP; gene variant; meta-analysis; microRNA
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- ref (ämneskategori)
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Park, Jae Hyon
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Jeong, Gwang Hun
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Lee, Kwang Seob
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Lee, Keum Hwa
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Suh, Jin-Soon
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Eisenhut, Michae ...
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Vliet, Hans J. v ...
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Kronbichler, And ...
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Stubbs, Brendon
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Solmi, Marco
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Dragioti, Elena
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Koyanagi, Ai
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Shin, Jae Il
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Gamerith, Gabrie ...
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