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Evidence-based umbr...
Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders
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- Carvalho, Andre F. (författare)
- Univ Toronto, Canada; Ctr Addict and Mental Hlth CAMH, Canada
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- Solmi, Marco (författare)
- Univ Padua, Italy; Kings Coll London, England
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- Sanches, Marcos (författare)
- Ctr Addict and Mental Hlth CAMH, Canada; Krembil Ctr NeuroInformat, Canada
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- Machado, Myrela O. (författare)
- Womens Coll Hosp, Canada
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- Stubbs, Brendon (författare)
- South London and Maudsley NHS Fdn Trust, England; Kings Coll London, England
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- Ajnakina, Olesya (författare)
- Kings Coll London, England
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- Sherman, Chelsea (författare)
- Sunnybrook Res Inst, Canada
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- Sun, Yue Ran (författare)
- Sunnybrook Res Inst, Canada
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- Liu, Celina S. (författare)
- Sunnybrook Res Inst, Canada
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- Brunoni, Andre R. (författare)
- Univ Sao Paulo, Brazil
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- Pigato, Giorgio (författare)
- Univ Padua, Italy
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- Fernandes, Brisa S. (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA
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- Bortolato, Beatrice (författare)
- Dept Mental Hlth ULSS 8 Berica, Italy
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- Husain, Muhammad I (författare)
- Univ Toronto, Canada; Ctr Addict and Mental Hlth CAMH, Canada
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- Dragioti, Elena (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Firth, Joseph (författare)
- Western Sydney Univ, Australia; Univ Manchester, England
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- Cosco, Theodore D. (författare)
- Simon Fraser Univ, Canada; Univ Oxford, England
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- Maes, Michael (författare)
- Chulalongkorn Univ, Thailand; Deakin Univ, Australia
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- Berk, Michael (författare)
- Deakin Univ, Australia; Orygen, Australia; Univ Melbourne, Australia; Univ Melbourne, Australia
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- Lanctot, Krista L. (författare)
- Univ Toronto, Canada; Ctr Addict and Mental Hlth CAMH, Canada; Sunnybrook Res Inst, Canada; Sunnybrook Res Inst, Canada; Univ Toronto, Canada
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- Vieta, Eduard (författare)
- Univ Barcelona, Spain
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- Pizzagalli, Diego A. (författare)
- Harvard Med Sch, MA 02478 USA
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- Smith, Lee (författare)
- Anglia Ruskin Univ, England
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- Fusar-Poli, Paolo (författare)
- Kings Coll London, England; South London and Maudsley Natl Hlth Serv Fdn Trust, England; Univ Pavia, Italy
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- Kurdyak, Paul A. (författare)
- Univ Toronto, Canada; Canada Inst Clin Evaluat Sci ICES, Canada; Ctr Addict and Mental Hlth CAMH, Canada
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- Fornaro, Michele (författare)
- Univ Sch Med Federico II, Italy
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- Rehm, Jurgen (författare)
- Univ Toronto, Canada; Ctr Addict and Mental Hlth CAMH, Canada; CAMH, Canada; Univ Toronto, Canada; Tech Univ Dresden, Germany; Tech Univ Dresden, Germany; Univ Toronto, Canada; IM Sechenov First Moscow State Med Univ, Russia
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- Herrmann, Nathan (författare)
- Univ Toronto, Canada; Sunnybrook Res Inst, Canada; Sunnybrook Res Inst, Canada
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(creator_code:org_t)
- 2020-05-18
- 2020
- Engelska.
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Ingår i: Translational Psychiatry. - : NATURE PUBLISHING GROUP. - 2158-3188. ; 10:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with conflicting results. An umbrella review of meta-analyses of non-genetic peripheral biomarkers for Alzheimers disease, autism spectrum disorder, bipolar disorder (BD), major depressive disorder, and schizophrenia, including first-episode psychosis. We included meta-analyses that compared alterations in peripheral biomarkers between participants with mental disorders to controls (i.e., between-group meta-analyses) and that assessed biomarkers after treatment (i.e., within-group meta-analyses). Evidence for association was hierarchically graded using a priori defined criteria against several biases. The Assessment of Multiple Systematic Reviews (AMSTAR) instrument was used to investigate study quality. 1161 references were screened. 110 met inclusion criteria, relating to 359 meta-analytic estimates and 733,316 measurements, on 162 different biomarkers. Only two estimates met a priori defined criteria for convincing evidence (elevated awakening cortisol levels in euthymic BD participants relative to controls and decreased pyridoxal levels in participants with schizophrenia relative to controls). Of 42 estimates which met criteria for highly suggestive evidence only five biomarker aberrations occurred in more than one disorder. Only 15 meta-analyses had a power >0.8 to detect a small effect size, and most (81.9%) meta-analyses had high heterogeneity. Although some associations met criteria for either convincing or highly suggestive evidence, overall the vast literature of peripheral biomarkers for major mental disorders is affected by bias and is underpowered. No convincing evidence supported the existence of a trans-diagnostic biomarker. Adequately powered and methodologically sound future large collaborative studies are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- Av författaren/redakt...
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Carvalho, Andre ...
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Solmi, Marco
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Sanches, Marcos
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Machado, Myrela ...
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Stubbs, Brendon
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Ajnakina, Olesya
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visa fler...
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Sherman, Chelsea
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Sun, Yue Ran
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Liu, Celina S.
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Brunoni, Andre R ...
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Pigato, Giorgio
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Fernandes, Brisa ...
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Bortolato, Beatr ...
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Husain, Muhammad ...
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Dragioti, Elena
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Firth, Joseph
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Cosco, Theodore ...
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Maes, Michael
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Berk, Michael
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Lanctot, Krista ...
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Vieta, Eduard
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Pizzagalli, Dieg ...
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Smith, Lee
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Fusar-Poli, Paol ...
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Kurdyak, Paul A.
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Fornaro, Michele
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Rehm, Jurgen
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Herrmann, Nathan
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