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Response to mechani...
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Dietrich, FrancieleLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten
(författare)
Response to mechanical loading in rat Achilles tendon healing is influenced by the microbiome
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-03-10
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PUBLIC LIBRARY SCIENCE,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-166508
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166508URI
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https://doi.org/10.1371/journal.pone.0229908DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Swedish Research CouncilSwedish Research Council [VR 02031-47-5]; Swedish National Centre for Research in Sports [P218-0140]; Linkoping University [LIO-698351]; Lions Research Foundation; Ostergotland Country Council [LIO-698351]
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We have previously shown that changes in the microbiome influence how the healing tendon responds to different treatments. The aim of this study was to investigate if changes in the microbiome influence the response to mechanical loading during tendon healing. 90 Sprague-Dawley rats were used. Specific Opportunist and Pathogen Free (SOPF) rats were co-housed with Specific Pathogen Free (SPF) rats, carrying Staphylococcus aureus and other opportunistic microbes. After 6 weeks of co-housing, the SOPF rats were contaminated which was confirmed by Staphylococcus aureus growth. Clean SOPF rats were used as controls. The rats were randomized to full loading or partial unloading by Botox injections in their calf muscles followed by complete Achilles tendon transection. Eight days later, the healing tendons were tested mechanically. The results were analysed by a 2-way ANOVA with interaction between loading and contamination on peak force as the primary outcome and there was an interaction for both peak force (p = 0.049) and stiffness (p = 0.033). Furthermore, partial unloading had a profound effect on most outcome variables. In conclusion, the response to mechanical loading during tendon healing is influenced by changes in the microbiome. Studies aiming for clinical relevance should therefore consider the microbiome of laboratory animals.
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Hammerman, MalinLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten(Swepub:liu)malha77
(författare)
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Eliasson, Pernilla T.Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten(Swepub:liu)perel67
(författare)
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Aspenberg, PerLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Ortopedkliniken i Linköping(Swepub:liu)peras36
(författare)
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Linköpings universitetAvdelningen för kirurgi, ortopedi och onkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PLOS ONE: PUBLIC LIBRARY SCIENCE15:31932-6203
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