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Polymorphism of FGF...
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Ansell, AnnaLinköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
(author)
Polymorphism of FGFR4 in cancer development and sensitivity to cisplatin and radiation in head and neck cancer
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Elsevier,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-16724
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16724URI
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https://doi.org/10.1016/j.oraloncology.2008.03.007DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The aim of this study was to investigate the predisposition of the FGFR4 Gly/Arg polymorphism for development of head and neck squamous cell carcinoma (HNSCC) and, furthermore, to examine if the FGFR4 Arg(388) allele can be associated with resistance to chemo-and radiotherapy.When analysing 110 tumour biopsies a significant 1.7-fold increased risk to develop HNSCC in individuals carrying the Gly(388) allele (p = 0.026) was found. Moreover a 2-fold increased risk for mates harbouring the Gly(388) allele (p = 0.031) to develop HNSCC was detected. In 39 HNSCC cell lines the role of the Arg(388) allele for radiation and cisplatin sensitivity was investigated. Our results show no rote of the Arg(388) allele for the radiosensitivity (p = 0.996) but indicate a tendency to increased cisplatin sensitivity (p = 0.141). When screening the transmembrane and kinase domains in the FGFR4 gene a novel mutation, probably generating a truncated protein lacking exons 14-18, was found in six of eight selected cell lines.Taken together, we have here identified a marker that predicts the risk to develop HNSCC and possibly the sensitivity to cisplatin as well as a novel. mutation in the FGFR4 gene.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Farnebo, LovisaÖstergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US(Swepub:liu)lovfa06
(author)
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Grénman, ReidarDepartment of Otorhinolaryngology, Head & Neck Surgery, and Medical Biochemistry, University of Turku, Finland
(author)
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Roberg, KarinÖstergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US(Swepub:liu)karro26
(author)
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Thunell, LenaLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)lenek59
(author)
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Linköpings universitetOto-Rhino-Laryngologi
(creator_code:org_t)
Related titles
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In:Oral Oncology: Elsevier45:1, s. 23-291368-83751879-0593
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