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Prominent Enhanceme...
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Yen, Ying-TzuNanjing Univ, Peoples R China
(författare)
Prominent Enhancement of Cisplatin Efficacy with Optimized Methoxy Poly(ethylene glycol)-Polycaprolactone Block Copolymeric Nanoparticles
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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AMER SCIENTIFIC PUBLISHERS,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-167316
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167316URI
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https://doi.org/10.1166/jbn.2020.2892DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81672398, 81972192, 81930080]; 5th group of "333 talent project" of Jiangsu Province [(2016)III-0119]; 14th group of six talent peak project in Jiangsu province [YY-068]; Medical youth talent project of Jiangsu Province [QNRC2016044]
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Chemotherapy has been one of the major standard treatments for a variety of cancers. cis-Dichlorodiamminoplatiunum(II) (cisplatin, CDDP), as one of the anticancer agents, demonstrated excellent efficacy against tumor and has been an indispensable component in chemotherapy, chemoradiation, chemo-molecular targeted therapy and chemo-immunotherapy. However, its therapeutic concentration was limited since its inevitable toxicity. Previously, we have constructed CDDP-loaded nanoparticles (NPs) with mixture of poly(ethyleneglycol)-polycaprolactone (PEG-PCL) and polycarprolactone (HO-PCL) by a facile method. The most optimal proportion of the two copolymers was selected through a series of physical, chemical, cytological and histological evaluations. In the present study, we explored the mechanisms of NPs and observed the in vivo antitumor effect after administrating CDDP-loaded PEG-PCL NPs. Positron emission tomography as well as computed tomography (PET/CT) were adopted for detecting tumoral metabolic activity. Images from fluorescence microscope revealed superior cellular uptake of CDDP-loaded NPs with rhodamine B aggregated intracellularly in cancer cells. Similar apoptotic rates between free CDDP group and CDDP-loaded NPs group was measured by flow cytometry. Tumor volumes and murine weights confirmed the superiority of CDDP-loaded NPs in therapeutic efficacy as compared with free CDDP. Blood tests showed milder side effects in CDDP-loaded nanoparticle group. PET/CT images illustrated less uptake intensity of FDG in mice received CDDP-loaded NPs than free CDDP. Our results suggest that PEG-PCL/PCL NPs could be a promising antitumor drug carrier for CDDP delivery with solid efficacy and minor side effects.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wang, XinyueNanjing Univ, Peoples R China
(författare)
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Zhang, HuanLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten(Swepub:liu)huazh47
(författare)
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Wang, ChunNanjing Univ, Peoples R China
(författare)
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Lin, ZitongNanjing Univ, Peoples R China
(författare)
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Xie, ChenNanjing Univ Posts and Elecommun, Ying-Tzu
(författare)
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Liu, QinNanjing Univ, Peoples R China
(författare)
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Wang, LifengNanjing Univ, Peoples R China
(författare)
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Yu, LixiaNanjing Univ, Peoples R China
(författare)
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Xie, LiNanjing Univ, Peoples R China
(författare)
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Lv, XinNanjing Univ, Peoples R China
(författare)
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Liu, BaoruiNanjing Univ, Peoples R China
(författare)
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Li, RutianNanjing Univ, Peoples R China
(författare)
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Nanjing Univ, Peoples R ChinaAvdelningen för barns och kvinnors hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Biomedical Nanotechnology: AMER SCIENTIFIC PUBLISHERS16:3, s. 335-3431550-70331550-7041
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Yen, Ying-Tzu
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Wang, Xinyue
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Zhang, Huan
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Wang, Chun
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Lin, Zitong
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Xie, Chen
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visa fler...
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Liu, Qin
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Wang, Lifeng
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Yu, Lixia
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Xie, Li
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Lv, Xin
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Liu, Baorui
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Li, Rutian
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