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  • Yen, Ying-TzuNanjing Univ, Peoples R China (författare)

Prominent Enhancement of Cisplatin Efficacy with Optimized Methoxy Poly(ethylene glycol)-Polycaprolactone Block Copolymeric Nanoparticles

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • AMER SCIENTIFIC PUBLISHERS,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-167316
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167316URI
  • https://doi.org/10.1166/jbn.2020.2892DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81672398, 81972192, 81930080]; 5th group of "333 talent project" of Jiangsu Province [(2016)III-0119]; 14th group of six talent peak project in Jiangsu province [YY-068]; Medical youth talent project of Jiangsu Province [QNRC2016044]
  • Chemotherapy has been one of the major standard treatments for a variety of cancers. cis-Dichlorodiamminoplatiunum(II) (cisplatin, CDDP), as one of the anticancer agents, demonstrated excellent efficacy against tumor and has been an indispensable component in chemotherapy, chemoradiation, chemo-molecular targeted therapy and chemo-immunotherapy. However, its therapeutic concentration was limited since its inevitable toxicity. Previously, we have constructed CDDP-loaded nanoparticles (NPs) with mixture of poly(ethyleneglycol)-polycaprolactone (PEG-PCL) and polycarprolactone (HO-PCL) by a facile method. The most optimal proportion of the two copolymers was selected through a series of physical, chemical, cytological and histological evaluations. In the present study, we explored the mechanisms of NPs and observed the in vivo antitumor effect after administrating CDDP-loaded PEG-PCL NPs. Positron emission tomography as well as computed tomography (PET/CT) were adopted for detecting tumoral metabolic activity. Images from fluorescence microscope revealed superior cellular uptake of CDDP-loaded NPs with rhodamine B aggregated intracellularly in cancer cells. Similar apoptotic rates between free CDDP group and CDDP-loaded NPs group was measured by flow cytometry. Tumor volumes and murine weights confirmed the superiority of CDDP-loaded NPs in therapeutic efficacy as compared with free CDDP. Blood tests showed milder side effects in CDDP-loaded nanoparticle group. PET/CT images illustrated less uptake intensity of FDG in mice received CDDP-loaded NPs than free CDDP. Our results suggest that PEG-PCL/PCL NPs could be a promising antitumor drug carrier for CDDP delivery with solid efficacy and minor side effects.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wang, XinyueNanjing Univ, Peoples R China (författare)
  • Zhang, HuanLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten(Swepub:liu)huazh47 (författare)
  • Wang, ChunNanjing Univ, Peoples R China (författare)
  • Lin, ZitongNanjing Univ, Peoples R China (författare)
  • Xie, ChenNanjing Univ Posts and Elecommun, Ying-Tzu (författare)
  • Liu, QinNanjing Univ, Peoples R China (författare)
  • Wang, LifengNanjing Univ, Peoples R China (författare)
  • Yu, LixiaNanjing Univ, Peoples R China (författare)
  • Xie, LiNanjing Univ, Peoples R China (författare)
  • Lv, XinNanjing Univ, Peoples R China (författare)
  • Liu, BaoruiNanjing Univ, Peoples R China (författare)
  • Li, RutianNanjing Univ, Peoples R China (författare)
  • Nanjing Univ, Peoples R ChinaAvdelningen för barns och kvinnors hälsa (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Biomedical Nanotechnology: AMER SCIENTIFIC PUBLISHERS16:3, s. 335-3431550-70331550-7041

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