Histological 3D reconstruction and in vivo lineage tracing of the human endometrium

Tempest, NicolaLiverpool Womens Hosp NHS Fdn Trust, England; Liverpool Hlth Partnership, England; Univ Liverpool, England (author)

Funding Agencies|Wellbeing of Women projectWellbeing of Women (WoW) [RTF510, RG2137]; Cancer Research UKCancer Research UK [A14895]
Regular menstrual shedding and repair of the endometrial functionalis is unique to humans and higher-order primates. The current consensus postulates endometrial glands to have a single-tubular architecture, where multi-potential stem cells reside in the blind-ending glandular-bases. Utilising fixed samples from patients, we have studied the three-dimensional (3D) micro-architecture of the human endometrium. We demonstrate that some non-branching, single, vertical functionalis glands originate from a complex horizontally interconnecting network of basalis glands. The existence of a multipotent endometrial epithelial stem cell capable of regenerating the entire complement of glandular lineages was demonstrated byin vivolineage tracing, using naturally occurring somatic mitochondrial DNA mutations as clonal markers. Vertical tracking of mutated clones showed that at least one stem-cell population resides in the basalis glands. These novel findings provide insight into the efficient and scar-less regenerative potential of the human endometrium. (c) 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Jansen, MarnixUCL, England (author)
Baker, Ann-MarieQueen Mary Univ London, England (author)
Hill, Christopher J.Liverpool Hlth Partnership, England (author)
Hale, MikeUniv Leeds, England (author)
Magee, DerekUniv Leeds, England; Heterogenius Ltd, England (author)
Treanor, DarrenLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk patologi,Univ Leeds, England; Leeds Teaching Hosp NHS Trust, England(Swepub:liu)dartr72 (author)
Wright, Nicholas A.Queen Mary Univ London, England (author)
Hapangama, Dharani K.Liverpool Womens Hosp NHS Fdn Trust, England; Liverpool Hlth Partnership, England; Univ Liverpool, England (author)
Liverpool Womens Hosp NHS Fdn Trust, England; Liverpool Hlth Partnership, England; Univ Liverpool, EnglandUCL, England (creator_code:org_t)

By the author/editor: Tempest, Nicola; Jansen, Marnix; Baker, Ann-Marie; Hill, Christophe ...; Hale, Mike; Magee, Derek; show more...; Treanor, Darren; Wright, Nicholas ...; Hapangama, Dhara ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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