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Nerve growth factor...
Nerve growth factor in serum of children with systemic lupus erythematosus is correlated with disease activity
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- Aalto, K (author)
- Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
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- Korhonen, L (author)
- Department of Neuroscience, Neurobiology, Uppsala University, Box 587, S-75123, Uppsala, Sweden
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- Lahdenne, P (author)
- Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
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- Pelkonen, P (author)
- Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
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- Lindholm, D (author)
- Department of Neuroscience, Neurobiology, Uppsala University, Box 587, S-75123, Uppsala, Sweden
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(creator_code:org_t)
- ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2002
- 2002
- English.
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In: Cytokine. - : ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. - 1043-4666 .- 1096-0023. ; 20:3, s. 136-139
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Nerve growth factor (NGF) is a neurotrophic factor, which is expressed both in the nervous system and in peripheral organs. NGF is also present in mast cells, and in B- and T-lymphocytes, and may play a role in the immune cell development and differentiation. Various cytokines have been shown to affect NGF expression, and NGF is elevated in inflammation and in some autoimmune diseases. Here we have studied NGF concentrations in serum of pediatric patients with systemic lupus erythematosus (SLE) using a two-site enzyme-linked immunosorbent assay (ELISA). We have further correlated the levels of NGF to the inflammatory state of the disease. The mean value of serum NGF in SLE patients was significantly increased compared with controls (3346 vs 627 pg/ml). There was a correlation between the activity of SLE and the levels of NGF. The results show that NGF is elevated in childhood SLE and that the levels are correlated with disease activity. The present results suggest that NGF may play a role in the pathogenesis of SLE and may have a prognostic value in evaluating the course of the disease and in outlining the medication. (C) 2002 Elsevier Science Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- SLE
- nerve growth factor
- enzyme-linked immunosorbent
- assay
- serum
- inflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
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