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Rotavirus A sheddin...
Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
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- Cantelli, Carina Pacheco (author)
- Fiocruz MS, Brazil; Fiocruz MS, Brazil
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- Velloso, Alvaro Jorge (author)
- Fiocruz MS, Brazil
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- Santos de Assis, Rosane Maria (author)
- Fiocruz MS, Brazil
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- Barros, Jose Junior (author)
- Fiocruz MS, Brazil
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- do Amaral Mello, Francisco Campello (author)
- Fiocruz MS, Brazil
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- da Cunha, Denise Cotrim (author)
- Fiocruz MS, Brazil
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- Brasil, Patricia (author)
- Fiocruz MS, Brazil
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- Nordgren, Johan (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Svensson, Lennart (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Miagostovich, Marize Pereira (author)
- Fiocruz MS, Brazil
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- Gagliardi Leite, Jose Paulo (author)
- Fiocruz MS, Brazil
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- de Moraes, Marcia Terezinha Baroni (author)
- Fiocruz MS, Brazil
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(creator_code:org_t)
- 2020-04-24
- 2020
- English.
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In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Recent studies have investigated whether the human histo-blood group antigen (HBGAs) could affect the effectiveness of the oral rotavirus vaccines, suggesting secretor positive individuals develop a more robust response. We investigated the Rotavirus A (RVA) shedding in association with the host susceptibility profile in children from a birth community-cohort in Rio de Janeiro, Brazil, from 2014 to 2018. A total of 132 children were followed-up between 0 to 11-month-old, stool samples were collected before/after the 1(st)/2(nd) RV1 vaccination doses and saliva samples were collected during the study. RVA shedding was screened by RT-qPCR and G/P genotypes determined by multiplex RT-PCR and/or Sanger nucleotide sequencing. The sequencing indicated an F167L amino acid change in the RV1 VP8* P[8] in 20.5% of shedding follow-ups and these mutant subpopulations were quantified by pyrosequencing. The HBGA/secretor status was determined and 80.3% of the children were secretors. Twenty-one FUT2 gene SNPs were identified and two new mutations were observed. The mutant F167L RV1 VP8* P[8] was detected significantly more in Le (a+b+) secretors (90.5%) compared to non-secretors and even to secretors Le (a-b+) (9.5%). The study highlights the probable association between RV1 shedding and HBGAs as a marker for evaluating vaccine strain host susceptibility.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- ref (subject category)
- art (subject category)
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Cantelli, Carina ...
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Velloso, Alvaro ...
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Santos de Assis, ...
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Barros, Jose Jun ...
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do Amaral Mello, ...
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da Cunha, Denise ...
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Brasil, Patricia
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Nordgren, Johan
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Svensson, Lennar ...
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Miagostovich, Ma ...
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Gagliardi Leite, ...
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de Moraes, Marci ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Scientific Repor ...
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Linköping University
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Karolinska Institutet