SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:liu-168841"
 

Sökning: id:"swepub:oai:DiVA.org:liu-168841" > Rotavirus A sheddin...

  • Cantelli, Carina PachecoFiocruz MS, Brazil; Fiocruz MS, Brazil (författare)

Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-04-24
  • NATURE PUBLISHING GROUP,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-168841
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168841URI
  • https://doi.org/10.1038/s41598-020-64025-0DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144387015URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Oswaldo Cruz Institute/Fiocruz/PAEF; "The Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro" (FAPERJ)Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) [E-26/202.968/2015]; "The National Council for Scientific and Technological Development" (CNPq)National Council for Scientific and Technological Development (CNPq) [424376/2016-4]; "Coordination for the Improvement of Higher Education Personnel - CAPES"- PrInt-Fiocruz-CAPESCAPES; PROGRAMA DE PROFESSOR VISITANTE NO EXTERIOR [88881.337140/2019-01]
  • Recent studies have investigated whether the human histo-blood group antigen (HBGAs) could affect the effectiveness of the oral rotavirus vaccines, suggesting secretor positive individuals develop a more robust response. We investigated the Rotavirus A (RVA) shedding in association with the host susceptibility profile in children from a birth community-cohort in Rio de Janeiro, Brazil, from 2014 to 2018. A total of 132 children were followed-up between 0 to 11-month-old, stool samples were collected before/after the 1(st)/2(nd) RV1 vaccination doses and saliva samples were collected during the study. RVA shedding was screened by RT-qPCR and G/P genotypes determined by multiplex RT-PCR and/or Sanger nucleotide sequencing. The sequencing indicated an F167L amino acid change in the RV1 VP8* P[8] in 20.5% of shedding follow-ups and these mutant subpopulations were quantified by pyrosequencing. The HBGA/secretor status was determined and 80.3% of the children were secretors. Twenty-one FUT2 gene SNPs were identified and two new mutations were observed. The mutant F167L RV1 VP8* P[8] was detected significantly more in Le (a+b+) secretors (90.5%) compared to non-secretors and even to secretors Le (a-b+) (9.5%). The study highlights the probable association between RV1 shedding and HBGAs as a marker for evaluating vaccine strain host susceptibility.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Velloso, Alvaro JorgeFiocruz MS, Brazil (författare)
  • Santos de Assis, Rosane MariaFiocruz MS, Brazil (författare)
  • Barros, Jose JuniorFiocruz MS, Brazil (författare)
  • do Amaral Mello, Francisco CampelloFiocruz MS, Brazil (författare)
  • da Cunha, Denise CotrimFiocruz MS, Brazil (författare)
  • Brasil, PatriciaFiocruz MS, Brazil (författare)
  • Nordgren, JohanLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)johno12 (författare)
  • Svensson, LennartKarolinska Institutet,Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)lensv66 (författare)
  • Miagostovich, Marize PereiraFiocruz MS, Brazil (författare)
  • Gagliardi Leite, Jose PauloFiocruz MS, Brazil (författare)
  • de Moraes, Marcia Terezinha BaroniFiocruz MS, Brazil (författare)
  • Fiocruz MS, Brazil; Fiocruz MS, BrazilFiocruz MS, Brazil (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scientific Reports: NATURE PUBLISHING GROUP10:12045-2322

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy