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NF-kappa B signalin...
NF-kappa B signaling in tanycytes mediates inflammation-induced anorexia
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- Boettcher, Mareike (author)
- Univ Lubeck, Germany
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- Mueller-Fielitz, Helge (author)
- Univ Lubeck, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- Sundaram, Sivaraj M. (author)
- Univ Lubeck, Germany
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- Gallet, Sarah (author)
- Jean Pierre Aubert Res Ctr, France; Univ Lille, France
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- Neve, Vanessa (author)
- Univ Lubeck, Germany
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- Shionoya, Kiseko (author)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Zager, Adriano (author)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Quan, Ning (author)
- Florida Atlantic Univ, FL 33458 USA
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- Liu, Xiaoyu (author)
- Florida Atlantic Univ, FL 33458 USA
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- Schmidt-Ullrich, Ruth (author)
- Max Delbruck Ctr MDC Mol Med, Germany
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- Haenold, Ronny (author)
- FLI, Germany; Friedrich Schiller Univ Jena, Germany
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- Wenzel, Jan (author)
- Univ Lubeck, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- Blomqvist, Anders (author)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Engblom, David (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Prevot, Vincent (author)
- Jean Pierre Aubert Res Ctr, France; Univ Lille, France
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- Schwaninger, Markus (author)
- Univ Lubeck, Germany; DZHK German Ctr Cardiovasc Res, Germany
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(creator_code:org_t)
- ELSEVIER, 2020
- 2020
- English.
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In: Molecular Metabolism. - : ELSEVIER. - 2212-8778. ; 39
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objectives: Infections, cancer, and systemic inflammation elicit anorexia. Despite the medical significance of this phenomenon, the question of how peripheral inflammatory mediators affect the central regulation of food intake is incompletely understood. Therefore, we have investigated the sickness behavior induced by the prototypical inflammatory mediator IL-1 beta. Methods: IL-1 beta was injected intravenously. To interfere with IL-1 beta signaling, we deleted the essential modulator of NF-kappa B signaling (Nemo) in astrocytes and tanycytes. Results: Systemic IL-1 beta increased the activity of the transcription factor NF-kB in tanycytes of the mediobasal hypothalamus (MBH). By activating NF-kappa B signaling, IL-1 beta induced the expression of cyclooxygenase-2 (Cox-2) and stimulated the release of the anorexigenic prostaglandin E-2 (PGE(2)) from tanycytes. When we deleted Nemo in astrocytes and tanycytes, the IL-1 beta-induced anorexia was alleviated whereas the fever response and lethargy response were unchanged. Similar results were obtained after the selective deletion of Nemo exclusively in tanycytes. Conclusions: Tanycytes form the brain barrier that mediates the anorexic effect of systemic inflammation in the hypothalamus. (C) 2020 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Tanycytes; In flammation-induced anorexia; IL-1 beta; NEMO
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Boettcher, Marei ...
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Mueller-Fielitz, ...
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Sundaram, Sivara ...
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Gallet, Sarah
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Neve, Vanessa
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Shionoya, Kiseko
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Zager, Adriano
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Quan, Ning
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Liu, Xiaoyu
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Schmidt-Ullrich, ...
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Haenold, Ronny
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Wenzel, Jan
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Blomqvist, Ander ...
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Engblom, David
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Prevot, Vincent
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Schwaninger, Mar ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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Molecular Metabo ...
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Linköping University