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Expresson of PTEN a...
Expresson of PTEN and SHP1, Ivestigated from Tissue Microarrays in Pediatric Acute Lymphoblastic, Leukemia
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- Gauffin, Fredrika (author)
- Karolinska Institutet,Karolinska University Hospital
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- Diffner, Eva (author)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Malmö University Hospital
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- Gustafsson, Bertil (author)
- Karolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Klinisk patologi och klinisk genetik
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- Nordgren, Ann (author)
- Karolinska Institutet,Karolinska Institute
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- Gjörloff Wingren, Anette (author)
- Malmö högskola,Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Malmö University Hospital,Fakulteten för hälsa och samhälle (HS)
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- Sander, Birgitta (author)
- Karolinska Institutet,Karolinska Institute
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- Persson, Jenny L., Professor (author)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
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- Gustafsson, Britt (author)
- Karolinska Institute
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(creator_code:org_t)
- 2009-07-09
- 2009
- English.
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In: Pediatric Hematology & Oncology. - : Informa UK Limited. - 0888-0018 .- 1521-0669. ; 26:1, s. 48-56
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Abstract
Subject headings
Close
- PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- pediatric leukemia
- PTEN
- SHP1
- tissue microarray
- MEDICINE
- MEDICIN
- SHP1
- tissue microarray
- pediatric leukemia
- PTEN
Publication and Content Type
- ref (subject category)
- art (subject category)
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