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Aberrant Salience I...
Aberrant Salience Is Related to Reduced Reinforcement Learning Signals and Elevated Dopamine Synthesis Capacity in Healthy Adults
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- Böhme, Rebecca (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
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- Deserno, Lorenz (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany
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- Gleich, Tobias (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
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- Katthagen, Teresa (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
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- Pankow, Anne (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
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- Behr, Joachim (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany; Institute of Neurophysiology, Charité Universitätsmedizin, Berlin, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical School Brandenburg, Neuruppin, Germany
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- Buchert, Ralph (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
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- Roiser, Jonathan P. (author)
- Institute of Cognitive Neuroscience, University College London, London, United Kingdom
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- Heinz, Andreas (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
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- Schlagenhauf, Florian (author)
- Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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(creator_code:org_t)
- Society for Neuroscience, 2015
- 2015
- English.
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In: Journal of Neuroscience. - : Society for Neuroscience. - 0270-6474 .- 1529-2401. ; 35:28, s. 10103-10111
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The striatum is known to play a key role in reinforcement learning, specifically in the encoding of teaching signals such as reward prediction errors (RPEs). It has been proposed that aberrant salience attribution is associated with impaired coding of RPE and heightened dopamine turnover in the striatum, and might be linked to the development of psychotic symptoms. However, the relationship of aberrant salience attribution, RPE coding, and dopamine synthesis capacity has not been directly investigated. Here we assessed the association between a behavioral measure of aberrant salience attribution, the salience attribution test, to neural correlates of RPEs measured via functional magnetic resonance imaging while healthy participants (n = 58) performed an instrumental learning task. A subset of participants (n = 27) also underwent positron emission tomography with the radiotracer [18F]fluoro-l-DOPA to quantify striatal presynaptic dopamine synthesis capacity. Individual variability in aberrant salience measures related negatively to ventral striatal and prefrontal RPE signals and in an exploratory analysis was found to be positively associated with ventral striatal presynaptic dopamine levels. These data provide the first evidence for a specific link between the constructs of aberrant salience attribution, reduced RPE processing, and potentially increased presynaptic dopamine function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Böhme, Rebecca
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Deserno, Lorenz
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Gleich, Tobias
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Katthagen, Teres ...
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Pankow, Anne
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Behr, Joachim
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show more...
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Buchert, Ralph
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Roiser, Jonathan ...
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Heinz, Andreas
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Schlagenhauf, Fl ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Neuro ...
- By the university
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Linköping University