Sökning: WFRF:(Deserno Lorenz) >
Prefrontal and Stri...
Prefrontal and Striatal Glutamate Differently Relate to Striatal Dopamine : Potential Regulatory Mechanisms of Striatal Presynaptic Dopamine Function?
-
- Gleich, Tobias (författare)
- Charité University Medicine Berlin, Berlin, Germany
-
- Deserno, Lorenz (författare)
- Charité University Medicine Berlin, Berlin, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
-
- Lorenz, Robert Christian (författare)
- Charité University Medicine Berlin, Berlin, Germany; Humboldt University, Berlin, Germany
-
visa fler...
-
- Böhme, Rebecca (författare)
- Charité University Medicine Berlin, Berlin, Germany
-
- Pankow, Anne (författare)
- Charité University Medicine Berlin, Berlin, Germany
-
- Buchert, Ralph (författare)
- Charité University Medicine Berlin, Berlin, Germany
-
- Kühn, Simone (författare)
- Charité University Medicine Berlin, Berlin, Germany; Max Planck Institute for Human Development, Berlin, Germany
-
- Heinz, Andreas (författare)
- Charité University Medicine Berlin, Berlin, Germany
-
- Schlagenhauf, Florian (författare)
- Charité University Medicine Berlin, Berlin, Germany; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
-
- Gallinat, Jürgen (författare)
- Charité University Medicine Berlin, Berlin, Germany; University Hospital Hamburg-Eppendorf, Hamburg, Germany
-
visa färre...
-
(creator_code:org_t)
- Society for Neuroscience, 2015
- 2015
- Engelska.
-
Ingår i: Journal of Neuroscience. - : Society for Neuroscience. - 0270-6474 .- 1529-2401. ; 35:26, s. 9615-9621
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Theoretical and animal work has proposed that prefrontal cortex (PFC) glutamate inhibits dopaminergic inputs to the ventral striatum (VS) indirectly, whereas direct VS glutamatergic afferents have been suggested to enhance dopaminergic inputs to the VS. In the present study, we aimed to investigate relationships of glutamate and dopamine measures in prefrontostriatal circuitries of healthy humans. We hypothesized that PFC and VS glutamate, as well as their balance, are differently associated with VS dopamine. Glutamate concentrations in the left lateral PFC and left striatum were assessed using 3-Tesla proton magnetic resonance spectroscopy. Striatal presynaptic dopamine synthesis capacity was measured by fluorine-18-l-dihydroxyphenylalanine (F-18-FDOPA) positron emission tomography. First, a negative relationship was observed between glutamate concentrations in lateral PFC and VS dopamine synthesis capacity (n = 28). Second, a positive relationship was revealed between striatal glutamate and VS dopamine synthesis capacity (n = 26). Additionally, the intraindividual difference between PFC and striatal glutamate concentrations correlated negatively with VS dopamine synthesis capacity (n = 24). The present results indicate an involvement of a balance in PFC and striatal glutamate in the regulation of VS dopamine synthesis capacity. This notion points toward a potential mechanism how VS presynaptic dopamine levels are kept in a fine-tuned range. A disruption of this mechanism may account for alterations in striatal dopamine turnover as observed in mental diseases (e.g., in schizophrenia).SIGNIFICANCE STATEMENT The present work demonstrates complementary relationships between prefrontal and striatal glutamate and ventral striatal presynaptic dopamine using human imaging measures: a negative correlation between prefrontal glutamate and presynaptic dopamine and a positive relationship between striatal glutamate and presynaptic dopamine are revealed. The results may reflect a regulatory role of prefrontal and striatal glutamate for ventral striatal presynaptic dopamine levels. Such glutamate–dopamine relationships improve our understanding of neurochemical interactions in prefrontostriatal circuits and have implications for the neurobiology of mental disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gleich, Tobias
-
Deserno, Lorenz
-
Lorenz, Robert C ...
-
Böhme, Rebecca
-
Pankow, Anne
-
Buchert, Ralph
-
visa fler...
-
Kühn, Simone
-
Heinz, Andreas
-
Schlagenhauf, Fl ...
-
Gallinat, Jürgen
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Journal of Neuro ...
- Av lärosätet
-
Linköpings universitet