Sökning: WFRF:(Wu Xiongyu 1972 ) >
Structure elucidati...
-
Wallgren, Jakob,1987-Linköpings universitet,Kemi,Tekniska fakulteten
(författare)
Structure elucidation of urinary metabolites of fentanyl and five fentanyl analogues using LC-QTOF-MS, hepatocyte incubations and synthesized reference standards
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
-
2020-02-27
-
Oxford University Press,2020
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-169944
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169944URI
-
https://doi.org/10.1093/jat/bkaa021DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding agencies: Strategiomradet Forensiska Vetenskaper (Strategic Research Area Forensic Sciences) at Linkoping University; Swedish Governmental Agency for Innovation SystemsVinnova; Eurostars-2 Joint Programme; European UnionEuropean Commission [E!10628]
-
Fentanyl analogues constitute a particularly dangerous group of new psychoactive compounds responsible for many deaths around the world. Little is known about their metabolism and studies utilizing LC-QTOF-MS analysis of hepatocyte incubations and/or authentic urine samples does not allow for determination of the exact metabolite structures, especially when it comes to hydroxylated metabolites. In this study seven motifs (2-, 3-, 4- and β-OH as well as 3,4-diOH, 4-OH-3-OMe and 3-OH-4-OMe) of fentanyl and five fentanyl analogues, acetylfentanyl, acrylfentanyl, cyclopropylfentanyl, isobutyrylfentanyl and 4F-isobutyrylfentanyl were synthesized. The reference standards were analyzed by LC-QTOF-MS, which enabled identification of the major metabolites formed in hepatocyte incubations of the studied fentanyls. By comparison with our previous data sets, major urinary metabolites could tentatively be identified. For all analogues, β-OH, 4-OH and 4-OH-3-OMe were identified after hepatocyte incubation. β-OH was the major hydroxylated metabolite for all studied fentanyls, except for acetylfentanyl where 4-OH was more abundant. However, the ratio 4-OH/β-OH was higher in urine samples than in hepatocyte incubations for all studied fentanyls. Also, 3-OH-4-OMe was not detected in any hepatocyte samples, indicating a clear preference for the 4-OH-3-OMe, which was also found to be more abundant in urine compared to hepatocytes. The patterns appear to be consistent across all studied fentanyls and could serve as a starting point in the development of methods and synthesis of reference standards of novel fentanyl analogues where nothing is known about the metabolism.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Vikingsson, Svante,1983-Linköpings universitet,Medicinska fakulteten,Avdelningen för läkemedelsforskning,Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping(Swepub:liu)svavi08
(författare)
-
Rautio, TobiasLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)tobra48
(författare)
-
Nasr, EnasLinköpings universitet,Institutionen för fysik, kemi och biologi,Tekniska fakulteten(Swepub:liu)n/a
(författare)
-
Åstrand, AnnaLinköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten(Swepub:liu)annas62
(författare)
-
Watanabe, ShimpeiDepartment of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping
(författare)
-
Kronstrand, Robert,1966-Linköpings universitet,Medicinska fakulteten,Avdelningen för läkemedelsforskning,Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping(Swepub:liu)robkr41
(författare)
-
Gréen, Henrik,1975-Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping(Swepub:liu)hengr89
(författare)
-
Dahlén, Johan,1969-Linköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)johda32
(författare)
-
Wu, Xiongyu,1972-Linköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)xiowu62
(författare)
-
Konradsson, Peter,1957-Linköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)petko14
(författare)
-
Linköpings universitetKemi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Analytical Toxicology: Oxford University Press44:90146-47601945-2403
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Wallgren, Jakob, ...
-
Vikingsson, Svan ...
-
Rautio, Tobias
-
Nasr, Enas
-
Åstrand, Anna
-
Watanabe, Shimpe ...
-
visa fler...
-
Kronstrand, Robe ...
-
Gréen, Henrik, 1 ...
-
Dahlén, Johan, 1 ...
-
Wu, Xiongyu, 197 ...
-
Konradsson, Pete ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Kemi
-
och Analytisk kemi
- Artiklar i publikationen
-
Journal of Analy ...
- Av lärosätet
-
Linköpings universitet