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  • Nishi, TomokoStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA (författare)

Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-05-09
  • OXFORD UNIV PRESS,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-170000
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170000URI
  • https://doi.org/10.1093/ehjci/jeaa070DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Stanford Diabetes Research Center [P30DK116074]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R18DK09639405, R01DK08137110]; Philips Royal Precision Medicine Initiative
  • Aims Resting echocardiography is a valuable method for detecting subclinical heart failure (HF) in patients with diabetes mellitus (DM). However, few studies have assessed the incremental value of diastolic stress for detecting subclinical HF in this population. Methods and results Asymptomatic patients with Type 2 DM were prospectively enrolled. Subclinical HF was assessed using systolic dysfunction (left ventricular longitudinal strain <16% at rest and <19% after exercise in absolute value), abnormal cardiac morphology, or diastolic dysfunction (E/e > 10). Metabolic equivalents (METs) were calculated using treadmill speed and grade, and functional capacity was assessed by percent-predicted METs (ppMETs). Among 161 patients studied (mean age of 59 +/- 11 years and 57% male sex), subclinical HF was observed in 68% at rest and in 79% with exercise. Among characteristics, diastolic stress had the highest yield in improving detection of HF with 57% of abnormal cases after exercise and 45% at rest. Patients with revealed diastolic dysfunction during stress had significantly lower exercise capacity than patients with normal diastolic stress (7.3 +/- 2.1 vs. 8.8 +/- 2.5, P < 0.001 for peak METs and 91 +/- 30% vs. 105 +/- 30%, P = 0.04 for ppMETs). On multivariable modelling found that age (beta = -0.33), male sex (beta = 0.21), body mass index (beta = -0.49), and exercise E/e >10 (beta = -0.17) were independently associated with peak METs (combined R-2 = 0.46). A network correlation map revealed the connectivity of peak METs and diastolic properties as central features in patients with DM. Conclusion Diastolic stress test improves the detection of subclinical HF in patients with diabetes mellitus.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kobayashi, YukariStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA (författare)
  • Christle, Jeffrey W.Stanford Univ, CA 94305 USA; Stanford Univ, CA 94305 USA (författare)
  • Cauwenberghs, NicholasUniv Leuven, Belgium (författare)
  • Boralkar, KalyaniStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA (författare)
  • Moneghetti, KeganStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA; Stanford Univ, CA 94305 USA (författare)
  • Amsallem, MyriamStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA (författare)
  • Hedman, KristoferLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US,Stanford Cardiovasc Inst, CA 94305 USA(Swepub:liu)krihe93 (författare)
  • Contrepois, KevinStanford Univ, CA 94305 USA (författare)
  • Myers, JonathanVet Affairs Palo Alto Healthcare Syst, CA 94304 USA; Stanford Univ, CA 94304 USA (författare)
  • Mahaffey, Kenneth W.Stanford Ctr Clin Res, CA 94305 USA (författare)
  • Schnittger, IngelaStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA (författare)
  • Kuznetsova, TatianaUniv Leuven, Belgium (författare)
  • Palaniappan, LathaStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA (författare)
  • Haddad, FrancoisStanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USA (författare)
  • Stanford Univ, CA 94305 USA; Stanford Cardiovasc Inst, CA 94305 USAStanford Univ, CA 94305 USA; Stanford Univ, CA 94305 USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Heart Journal Cardiovascular Imaging: OXFORD UNIV PRESS21:8, s. 876-8842047-24042047-2412

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