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The methylation lan...
The methylation landscape and its role in domestication and gene regulation in the chicken
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- Höglund, Andrey, 1985- (författare)
- Linköpings universitet,Biologi,Tekniska fakulteten,AVIAN Behavioural Genomics and Physiology Group,Linköping Univ, AVIAN Behav Genom & Physiol Grp, Linköping, Sweden.
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- Henriksen, Rie, 1981- (författare)
- Linköpings universitet,Biologi,Tekniska fakulteten,AVIAN Behavioural Genomics and Physiology Group,Linköping Univ, AVIAN Behav Genom & Physiol Grp, Linköping, Sweden.
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- Fogelholm, Jesper, 1986- (författare)
- Linköpings universitet,Biologi,Tekniska fakulteten,AVIAN Behavioural Genomics and Physiology Group,Linköping Univ, AVIAN Behav Genom & Physiol Grp, Linköping, Sweden.
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- Churcher, Allison M. (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),NBIS, Department of Molecular Biology, Umeå University, Umeå, Sweden,Umeå Univ, Dept Mol Biol, NBIS, Umeå, Sweden.
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- Guerrero-Bosagna, Carlos M., 1975- (författare)
- Uppsala universitet,Linköpings universitet,Biologi,Tekniska fakulteten,Evolutionary Biology Centrum, Dept of Organismal Biology, Uppsala University, Uppsala, Sweden,AVIAN Behavioural Genomics and Physiology Group,Miljötoxikologi,Linköping Univ, AVIAN Behav Genom & Physiol Grp, Linköping, Sweden.
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- Martínez Barrio, Álvaro, 1977- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för cell- och molekylärbiologi
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- Johnsson, Martin (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,University of Edinburgh
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- Jensen, Per, 1956- (författare)
- Linköpings universitet,Biologi,Tekniska fakulteten,AVIAN Behavioural Genomics and Physiology Group,Linköping Univ, AVIAN Behav Genom & Physiol Grp, Linköping, Sweden.
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- Wright, Dominic, 1977- (författare)
- Linköpings universitet,Biologi,Tekniska fakulteten,AVIAN Behavioural Genomics and Physiology Group,Linköping Univ, AVIAN Behav Genom & Physiol Grp, Linköping, Sweden.
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(creator_code:org_t)
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- 2020-09-21
- 2020
- Engelska.
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Ingår i: Nature Ecology & Evolution. - : Springer Nature. - 2397-334X. ; 4, s. 1713-1724
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- Domestication is one of the strongest examples of artificial selection and has produced some of the most extreme within-species phenotypic variation known. In the case of the chicken, it has been hypothesized that DNA methylation may play a mechanistic role in the domestication response. By inter-crossing wild-derived red junglefowl with domestic chickens, we mapped quantitative trait loci for hypothalamic methylation (methQTL), gene expression (eQTL) and behaviour. We find large, stable methylation differences, with 6,179 cis and 2,973 trans methQTL identified. Over 46% of the trans effects were genotypically controlled by five loci, mainly associated with increased methylation in the junglefowl genotype. In a third of eQTL, we find that there is a correlation between gene expression and methylation, while statistical causality analysis reveals multiple instances where methylation is driving gene expression, as well as the reverse. We also show that methylation is correlated with some aspects of behavioural variation in the inter-cross. In conclusion, our data suggest a role for methylation in the regulation of gene expression underlying the domesticated phenotype of the chicken.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience -- Animal and Dairy Science. (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Höglund, Andrey, ...
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Henriksen, Rie, ...
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Fogelholm, Jespe ...
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Churcher, Alliso ...
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Guerrero-Bosagna ...
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Martínez Barrio, ...
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Johnsson, Martin
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Jensen, Per, 195 ...
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Wright, Dominic, ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Husdjursvetenska ...
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och Husdjursvetenska ...
- Artiklar i publikationen
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Nature Ecology & ...
- Av lärosätet
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Linköpings universitet
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Umeå universitet
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Uppsala universitet
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Sveriges Lantbruksuniversitet