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- Kaipe, HelenKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
MAIT Cells at the Fetal-Maternal Interface During Pregnancy
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-08-19
- FRONTIERS MEDIA SA,2020
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-170687
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170687URI
- https://doi.org/10.3389/fimmu.2020.01788DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:144692190URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Funding Agencies|Swedish Research CouncilSwedish Research Council [2019-01311, 2018-02776]; Karolinska InstitutetKarolinska Institutet; Medical Inflammation and Infection Center (MIIC); Linkoping University
- One of the main functions of the human placenta is to provide a barrier between the fetal and maternal blood circulations, where gas exchange and transfer of nutrients to the developing fetus take place. Despite being a barrier, there is a multitude of crosstalk between maternal immune cells and fetally derived semi-allogeneic trophoblast cells. Therefore, the maternal immune system has a difficult task to both tolerate the fetus but at the same time also defend the mother and the fetus from infections. Mucosal-associated invariant T (MAIT) cells are an increasingly recognized subset of T cells with anti-microbial functions that get activated in the context of non-polymorphic MR1 molecules, but also in response to inflammation. MAIT cells accumulate at term pregnancy in the maternal blood that flows into the intervillous space inside the placenta. Chemotactic factors produced by the placenta may be involved in recruiting and retaining particular immune cell subsets, including MAIT cells. In this Mini-Review, we describe what is known about MAIT cells during pregnancy and discuss the potential biological functions of MAIT cells at the fetal-maternal interface. Since MAIT cells have anti-microbial and tissue-repairing functions, but lack alloantigen reactivity, they could play an important role in protecting the fetus from bacterial infections and maintaining tissue homeostasis without risks of mediating harmful responses toward semi-allogenic fetal tissues.
Subject headings and genre
- NATURVETENSKAP Biologi Immunologi hsv//swe
- NATURAL SCIENCES Biological Sciences Immunology hsv//eng
- MAIT cells; placenta; pregnancy; decidua; intervillous blood
Added entries (persons, corporate bodies, meetings, titles ...)
- Raffetseder, JohannaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)johra57 (author)
- Ernerudh, JanLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15 (author)
- Solders, MartinKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
- Tiblad, EleonorKarolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden (author)
- Karolinska InstitutetKarolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (creator_code:org_t)
Related titles
- In:Frontiers in Immunology: FRONTIERS MEDIA SA111664-3224
Internet link
- https://liu.diva-portal.org/smash/get/diva2:1477682/FULLTEXT01.pdffulltext:print
- https://www.frontiersin.org/articles/10.3389/fimmu.2020.01788/pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170687
- https://doi.org/10.3389/fimmu.2020.01788
- http://kipublications.ki.se/Default.aspx?queryparsed=id:144692190
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