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Pregnancies, ventri...
Pregnancies, ventricular arrhythmias, and substrate progression in women with arrhythmogenic right ventricular cardiomyopathy in the Nordic ARVC Registry
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- Platonov, Pyotr G. (author)
- Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Department of Cardiology, Clinical Sciences, Lund University, 22185 Lund, Sweden
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- Castrini, Anna I (author)
- Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute for clinical Medicine, University of Oslo, Oslo, Norway
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- Svensson, Anneli, 1972- (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Christiansen, Morten K (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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- Gilljam, Thomas (author)
- Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Bundgaard, Henning (author)
- Department of Cardiology, Centre of Cardiac-, Vascular-, Pulmonary- and Infectious Diseases, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Copenhagen University Hospital
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- Madsen, Trine (author)
- Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Heliö, Tiina (author)
- Department of Cardiology, Helsinki University Hospital, Helsinki, Finland,Helsinki University Central Hospital
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- Christensen, Alex H (author)
- Department of Cardiology, Herlev-Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
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- Åström Aneq, Meriam, 1964- (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
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- Carlson, Jonas (author)
- Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Department of Cardiology, Clinical Sciences, Lund University, 22185 Lund, Sweden
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- Edvardsen, Thor (author)
- Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute for clinical Medicine, University of Oslo, Oslo, Norway
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- Jensen, Henrik K (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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- Haugaa, Kristina H (author)
- Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute for clinical Medicine, University of Oslo, Oslo, Norway
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- Svendsen, Jesper H (author)
- Department of Cardiology, Centre of Cardiac-, Vascular-, Pulmonary- and Infectious Diseases, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Copenhagen University Hospital
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(creator_code:org_t)
- 2020-07-18
- 2020
- English.
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In: Europace. - : Oxford University Press. - 1099-5129 .- 1532-2092. ; 23:12, s. 1873-1879
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- AIMS: Women with arrhythmogenic right ventricular cardiomyopathy (ARVC) are at relatively lower risk of ventricular arrhythmias (VAs) than men, but the physical burden associated with pregnancy on VA risk remains insufficiently studied. We aimed to assess the risk of VA in relation to pregnancies in women with ARVC.METHODS AND RESULTS: We included 199 females with definite ARVC (n = 121) and mutation-positive family members without ascertained ARVC diagnosis (n = 78), of whom 120 had at least one childbirth. Ventricular arrhythmia-free survival after the latest childbirth was compared between women with one (n = 20), two (n = 67), and three or more (n = 37) childbirths. Cumulative probability of VA for each pregnancy (n = 261) was assessed from conception through 2 years after childbirth and compared between those pregnancies that occurred before (n = 191) or after (n = 19) ARVC diagnosis and in mutation-positive family members (n = 51). The nulliparous women had lower median age at ARVC diagnosis (38 vs. 42 years, P < 0.001) and first VA (22 vs. 41 years, P < 0.001). Ventricular arrhythmia-free survival after the latest childbirth was not related to the number of pregnancies. No pregnancy-related VA was reported among the family members. Women who gave birth after ARVC diagnosis had elevated risk of VA postpartum (hazard ratio 13.74, 95% confidence interval 2.9-63, P = 0.001), though only two events occurred during pregnancies.CONCLUSION: In women with ARVC, pregnancy was uneventful for the overwhelming majority and the number of prior completed pregnancies was not associated with VA risk. Pregnancy-related VA was primarily related to the phenotypical severity rather than pregnancy itself.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Arrhythmogenic right ventricular cardiomyopathy
- Pregnancy
- Risk stratification
- Arrhythmogenic right ventricular cardiomyopathy
- Pregnancy
- Risk stratification
Publication and Content Type
- ref (subject category)
- art (subject category)
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Europace
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Platonov, Pyotr ...
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Castrini, Anna I
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Svensson, Anneli ...
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Christiansen, Mo ...
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Gilljam, Thomas
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Bundgaard, Henni ...
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Madsen, Trine
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Heliö, Tiina
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Christensen, Ale ...
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Åström Aneq, Mer ...
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Carlson, Jonas
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Edvardsen, Thor
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Jensen, Henrik K
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Haugaa, Kristina ...
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Svendsen, Jesper ...
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- MEDICAL AND HEALTH SCIENCES
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Europace
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Linköping University
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