Search: id:"swepub:oai:DiVA.org:liu-17143" >
The Ile646Val (2073...
-
Wang, Mo-JinSichuan University
(author)
The Ile646Val (2073A > G) Polymorphism in the Kinase-Binding Domain of A-Kinase Anchoring Protein 10 and the Risk of Colorectal Cancer
- Article/chapterEnglish2009
Publisher, publication year, extent ...
-
2009-02-11
-
S. Karger AG,2009
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:liu-17143
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17143URI
-
https://doi.org/10.1159/000201572DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Objective: The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC. Methods: Applying TaqMan allelic discrimination, we investigated AKAP10 Ile646Val (2073A>G) polymorphism in 288 Chinese CRC patients and 281 healthy controls. Results: Logistic regression analysis revealed a significant association of AKAP10 Ile646Val (2073A>G) polymorphism with increased CRC risk (adjusted OR = 1.44, 95% CI 1.01-2.07, p = 0.02). Stratification analysis showed that the increased risk associated with the variant genotypes (GG+AG) was more evident in male subjects (adjusted OR = 1.48, 95% CI 0.94-2.34, p = 0.03). Compared with the AA genotype, the adjusted OR for the variant genotypes was 1.81 (95% CI 1.08 - 3.05, p = 0.01) among young subjects (age ! 57 years). Among individuals who did not smoke or who smoked lightly, there was a significantly increased risk with the variant genotypes (adjusted OR = 1.66, 95% CI 1.08 - 2.56, p = 0.02). We did not observe a relationship between the AKAP10 polymorphism and other clinicopathological and environmental factors. Conclusions: Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population.
Subject headings and genre
-
A-kinase anchoring protein 10
-
Polymorphism
-
2073A >
-
G
-
Colorectal cancer
-
MEDICINE
-
MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
-
Zhou, Zong-GuangSichuan University
(author)
-
Wang, LingSichuan University
(author)
-
Yu, Yong-YangSichuan University
(author)
-
Zhang, PengSichuan University
(author)
-
Zhang, YiSichuan University
(author)
-
Cui, Chang-FuSichuan University
(author)
-
Yang, LieSichuan University
(author)
-
Li, YuanSichuan University
(author)
-
Zhou, BinSichuan University
(author)
-
Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45
(author)
-
Sichuan UniversityOnkologi
(creator_code:org_t)
Related titles
-
In:ONCOLOGY: S. Karger AG76:3, s. 199-2040030-24141423-0232
Internet link
Find in a library
-
ONCOLOGY
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Wang, Mo-Jin
-
Zhou, Zong-Guang
-
Wang, Ling
-
Yu, Yong-Yang
-
Zhang, Peng
-
Zhang, Yi
-
show more...
-
Cui, Chang-Fu
-
Yang, Lie
-
Li, Yuan
-
Zhou, Bin
-
Sun, Xiao-Feng
-
show less...
- Articles in the publication
-
ONCOLOGY
- By the university
-
Linköping University