The Ile646Val (2073A > G) Polymorphism in the Kinase-Binding Domain of A-Kinase Anchoring Protein 10 and the Risk of Colorectal Cancer

Objective: The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC. Methods: Applying TaqMan allelic discrimination, we investigated AKAP10 Ile646Val (2073A>G) polymorphism in 288 Chinese CRC patients and 281 healthy controls. Results: Logistic regression analysis revealed a significant association of AKAP10 Ile646Val (2073A>G) polymorphism with increased CRC risk (adjusted OR = 1.44, 95% CI 1.01-2.07, p = 0.02). Stratification analysis showed that the increased risk associated with the variant genotypes (GG+AG) was more evident in male subjects (adjusted OR = 1.48, 95% CI 0.94-2.34, p = 0.03). Compared with the AA genotype, the adjusted OR for the variant genotypes was 1.81 (95% CI 1.08 - 3.05, p = 0.01) among young subjects (age ! 57 years). Among individuals who did not smoke or who smoked lightly, there was a significantly increased risk with the variant genotypes (adjusted OR = 1.66, 95% CI 1.08 - 2.56, p = 0.02). We did not observe a relationship between the AKAP10 polymorphism and other clinicopathological and environmental factors. Conclusions: Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population.

Zhou, Zong-GuangSichuan University (author)
Wang, LingSichuan University (author)
Yu, Yong-YangSichuan University (author)
Zhang, PengSichuan University (author)
Zhang, YiSichuan University (author)
Cui, Chang-FuSichuan University (author)
Yang, LieSichuan University (author)
Li, YuanSichuan University (author)
Zhou, BinSichuan University (author)
Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
Sichuan UniversityOnkologi (creator_code:org_t)

By the author/editor: Wang, Mo-Jin; Zhou, Zong-Guang; Wang, Ling; Yu, Yong-Yang; Zhang, Peng; Zhang, Yi; show more...; Cui, Chang-Fu; Yang, Lie; Li, Yuan; Zhou, Bin; Sun, Xiao-Feng; show less...

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